Application of High Performance Liquid Chromatography to the Analysis of Crude Drugs : Separatory Determination of Saponins of Bupleuri Radix
スポンサーリンク
概要
- 論文の詳細を見る
The optimal conditions for conversion of saikosaponins-a (1) and -d (3), the pharmacologically active major saponins of roots of Bupleurum falcatum, into diene-saponins (saikosaponins-b_1 (4) and -b_2 (6)) was investigated. By means of high performance liquid chromatography (HPLC) on an octadecylsilylated silica gel column, complete separation and highly sensitive quantitative analysis of these diene-saponins, which exhibit characteristic ultraviolet maxima, were possible, offering a rapid and selective procedure for the determination of 1 and 3 in commercial samples of Bupleuri radix. Some of the crude drugs on the Japanese market were evaluated by this procedure and it was found that the HPLC pattern of "Chiku-Saiko" imported from Korea was different from those of other crude drugs and cultivated B. falcatum, but similar to that of roots of B. longeradiatum, supporting the morphological comparison of Konoshima et al.
- 公益社団法人日本薬学会の論文
- 1979-08-25
著者
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田中 治
Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine
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石川 治
大阪市工研
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木全 裕子
広島大学医学部総合薬学科
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矢原 正治
Faculty Of Pharmaceutical Sciences Kyushu University 62
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相浦 惇
Institute of Toyo Soda Manufacturing Co., Ltd.
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田中 治
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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相浦 惇
Institute Of Toyo Soda Manufacturing Co. Ltd.
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