Xanthone Glucosides of Swertia japonica MAKINO and a Related Plant : Structure of a New Glucoside, Isoswertianolin and Structure Revision of Swertianolin and Norswertianolin
スポンサーリンク
概要
- 論文の詳細を見る
A new xanthone glucoside named isoswertianolin (2) was isolated from Swertia japonica and its structure was elucidated to be 5-O-β-glucopyranoside of bellidifolin by ^1H and ^<13>C nuclear magnetic resonance (NMR) spectroscopy. In connection with this study, the structure of swertianolin (1), a constituent of this plant, was reinvestigated by NMR spectroscopy, leading to the revision of its structure (the location of its glucosyl linkage) from 1-O-β-glucopyranoside of bellidifolin (3) to 8-O-β-glucopyranoside of 3. It follows that 1 is identical with the glucoside isolated from Gentiana campestris by Kaldas et al. in 1974. Analogously, the structure of norswertianolin (6), previously isolated from Swertia randaiensis HAYATA, was also revised, being formulated as 8-O-β-glucopyranoside of desmethylbellidifolin (7).
- 公益社団法人日本薬学会の論文
- 1982-11-25
著者
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田中 治
Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine
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富森 毅
School of Pharmacy, Hokuriku University
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田中 崇嗣
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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田中 崇嗣
Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.,
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田中 崇嗣
Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.
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坂本 征則
Hiroshima Prefectural Institute of Public Health
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富森 毅
School Of Pharmacy Hokuriku University
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田中 治
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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