Studies on Nepalese Crude Drugs. XIV. New Flavonoids from the Root of Scutellaria prostrata JACQ. ex BENTH.

概要

論文の詳細を見る
Six flavonoids, named scutellaprostins A, B, C, D, E and F, were isolated from teh root of Scutellaria prostrata JACQ. ex BENTH. (Labiatae). Their structures were established to be (2R^*, 3R^*)-6-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-9-phenyl-2,3-dihydro-7H-1,4-dioxino[2,3-h]chromene-7-one (I), (2R^*, 3^*)-6-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-9-(4-hydroxyphenyl)-2,3-dihydro-7H-1,4-dioxino[2,3-h]-chromene-7-one (II), (2R^*, 3R^*)-6-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-9-(3,4-dihydroxyphenyl)-2,3-dihydro-7H-1,4-dioxino-[2,3-h]chromene-7-one (III), (2R^*, 3R^*)-5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-8-phenyl-2,3-dihydro-6H-1,4-dioxino-[2,3-g]chromene-6-one (IV), (2R^*, 3R^*)-5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-8-(4-hydroxyphenyl)-2,3-dihydro-6H-1,4-dioxino[2,3-g]chromene-6-one (V) and (2R^*, 3R^*)-5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3-hydroxymethyl-8-(3,4-dihydroxyphenyl)-2,3-dihydro-6H-1,4-dioxino[2,3-g]chromene-6-one (VI), respectively, by chemical and spectral data. They were synthesized by oxidative coupling of the flavones and coniferyl alcohol in the presence of silver oxide.
社団法人日本薬学会の論文
1991-06-25