The Effect of Dosage Form on Absorption of Vitamin A into Lymph
スポンサーリンク
概要
- 論文の詳細を見る
Some effects of dosage form on absorption of vitamin A into thoracic duct were studied in rats fed vitamin A. Forty-five % of administered vitamin A was recovered in lymph when vitamin A was given in micellar solution form, while 29% of administered vitamin A was recovered when vitamin A was given in triolein solution form. The time courses of appearance of vitamin A in lymph of these two kinds of preparation were very different one another. Vitamin A appearance in lymph showed a sharp peak between 1 and 2 hr after the administration in micellar solution form and indicated the almost complete absorption of vitamin A, while it showed a broad band over 4 hr after the administration in oily solution form. The time courses of vitamin A in serum did not exactly reflect those in lymph.
- 公益社団法人日本薬学会の論文
- 1976-12-25
著者
-
西垣 隆一郎
東邦大学薬学部
-
西垣 隆一郎
東邦大・薬
-
西垣 隆一郎
東邦大学薬学部薬物動態学教室
-
花野 学
Faculty of Pharmaceutical Sciences, University of Tokyo
-
不破 亨
Central Research Lab., Wakunaga Pharmaceutical Co.
-
不破 亨
Central Research Lab. Wakunaga Pharmaceutical Co.
-
花野 学
Faculty Of Pharmaceutical Sciences University Of Tokyo
-
不破 亨
Wakunaga Pharmaceutical Co., Ltd.
関連論文
- 実験乳癌に対する音響化学療法の効果
- 30P1-144 CimetidineによるCYP2C阻害形式の検討(薬物相互作用(基礎と臨床),医療薬学の扉は開かれた)
- 薬物代謝酵素誘導の速度論的解析 - phenobarbitalによるCYP2B誘導 -
- 肝代謝と肝取り込みの同時評価系の構築 - ミダゾラム代謝とそれに対する阻害効果 -
- Binding of Human Epidermal Growth Factor to Tissue Homogenates of the Rat(Pharmaceutical,Chemical)
- Leukotriene B4 receptor antagonist ONO-4057のラット肝取り込み機構の解析
- HL-60細胞においてハイパーサーミアにより誘導されるアポトーシスにおけるカスパーゼ-3,8および9経路の関与
- 低侵襲治療への音響化学的アプローチ
- 音響化学効果を利用した治療
- 癌治療への音響化学的アプローチ
- 超音波による音響化学活性物質の局所活性化とがん治療への応用
- Pharmacokinetic Studies of the Inhibition of Glucuronization of Pentazocine by Salicylamide
- The Conjugative Metabolism of 4-Methylumbelliferone and Deconjugation to the Parent Drug Examined by Isolated Perfused Liver and in Vitro Liver Homogenate of Rats
- Studies on Ligand Binding Properties of Z-Fraction from Rat Liver Cytosol using 1-Anilino-8-Naphthalenesulfonate
- Pharmacokinetic Studies of Biliary Excretion. IV. The Relationship between the Biliary Excretion Behavior and the Elimination from Plasma of Azo Dyes and Triphenylmethane Dyes in Rat
- インドメサシンの生物薬剤学的研究(第2報) : ラット小腸管吸収機構およびヒト経口投与時における微粉化製剤の利用率
- Pharmacokinetic Studies of Biliary Excretion. I. Comparison of the Excretion Behavior in Azo Dyes and Indigo Carmine
- Pharmacokinetic Aspects of Biliary Excretion. Dose Dependency of Riboflavin in Rat
- サリチル酸による肝細胞障害における脂質過酸化とATPの変動
- 1.2価の有機陰イオンmethotrexate (MTX)の肝取り込み・胆汁排泄機構の解析
- 薬物の肝胆系移行の速度論的解析 : 担体輸送の重要性
- HMG-CoA reductase阻害剤pravastatinの肝取り込み, 胆汁排泄における非線形動態の解析
- Syntemic Effects of Epidermal Growth Factor (EGF) Ointment Containing Protease Inhibitor or Gelatin in Rats with Burns or Open Wounds
- Generalized Consideration of Administration Route Dependence of Drug Disposition and Use of Urinary Data for Prediction of the Dependence
- Biliary Excretion Behavior Difference of Quaternary Ammonium Compounds between Portal Vein and Femoral Vein Infusion in Rat
- DDS-その軌跡と将来
- Conjugative Metabolism of 4-Methylumbelliferone in the Rat Liver : Verification of the Sequestration Process in Multiple Indicator Dilution Experiments(Pharmaceutical,Chemical)
- Effect of Urea on Intestinal Absorption of Salicylic Acid, Benzoic Acid and Aminopyrine in Rat
- Amides from Huajiao, Pericarps of Zanthoxylum bungeanum MAXIM.
- Studies on Absorption and Excretion of Drugs. V. On the Mechanism of Penetration of Sulfisomezole through the Intestinal Barrier in vitro
- Studies on Absorption and Excretion of Drugs. III. Kinetics of Penetration of Sulfonamides through the Intestinal Barrier in Vitro.
- Hepatic Drug Clearance Model : Comparison among the Distributed, Parallel-Tube and Well-Stirred Models
- Chemical Studies on Chinese Traditional Medicine, Dangshen. I. : Isolation of (Z)-3- and (E)-2-Hexenyl β-D-Glucosids
- The Pharmacokinetic Study on the Fate of 8-Hydroxyquinoline in Rat
- A New Numerical Calculation Method for Deconvolution in Linear Compartment Analysis of Pharmacokinetics
- Kinetic Studies on Decomposition of Glutathione. III. Peptide Bond Cleavage and Desulfurization in Aqueous Solution
- Kinetic Studies on Decomposition of Glutathione. II. Anaerobic Decomposition in Aqueous Solution
- Kinetic Studies on Decomposition of Glutathione. I. Decomposition in Solid State
- Studies on Absorption and Excretion of Drugs. VI. Effects of Cations and 2,4-Dinitrophenol on the Transport of Sulfonamides through the Small Intestine of Rat
- Chemical Evaluation of Bupleurum Species Collected in Yunnan, China
- Further Studies on Dammarane-Saponins of Sanchi-Ginseng
- Dammarane-Saponins of Sanchi-Ginseng, Roots of Panax notoginseng (BURK.) F.H. CHEN (Araliaceae) : Structures of New Saponins, Notoginsenosides-R1 and -R2,and Identification of Ginsenosides-Rg_2 and -Rh_1
- P2-146 マウスにおけるdanazolとmidazolamの薬物相互作用におよぼす投与間隔の影響(一般演題 ポスター発表,薬物相互作用,臨床から学び臨床へと還元する医療薬学)
- Pharmacokinetic Aspects of Elimination from Plasma and Distribution to Brain and Liver of Barbiturates in Rat
- Thiamine Derivatives of Disulfide Type. XIV. Kinetic Studies on the Reaction between Thiamine and Propyl Propane-Thiolsulfinate or -Thiolsulfonate
- Pharmacokinetics of Thiamine Derivatives. II. Elimination of Thiamine Derivatives from the Blood of Rat
- Pharmacokinetics of Thiamine Derivatives. I. Formation of Thiamine from Thiamine Propyl Disulfide by Erythrocytes of Rat
- Saponins of Red Ginseng
- Further Studies on Dammarane-Saponins of American Ginseng, Roots of Panax quinquefolium L.
- Ginsenoside-Ra_1 and Ginsenoside-Ra_2,New Dammarane-Saponins of Ginseng Roots
- Thin-Layer Chromatographic Determination of Panaxadiol and Panaxatriol by Ultraviolet Derivatization
- Solubilization of dl-α-Tocopherol by Bile Salts, Polysorbate 80 and Egg Lecithin
- In Vivo and In Vitro Fates of 8-Hydroxyquinoline Derivatives in Rat
- Various Factors affecting Intestinal Absorption of Iodochlorhydroxyquin in Rat and Man
- Differences in Species of Iodochlorhydroxyquin Absorption, Metabolism, and Excretion
- Effects of Albumin and α_1-Acid Glycoprotein on the Transport of Imipramine and Desipramine through the Blood-Brain Barrier in Rats(Pharmaceutical)
- Relationship between the Morphological Character of 5-Nitroacetyl-salicylic Acid Crystals and the Decomposition Rate in a Humid Environment
- P2-147 ラットにおけるmidazolamによるmechanism based inhibitionの検討(一般演題 ポスター発表,薬物相互作用,臨床から学び臨床へと還元する医療薬学)
- ALLXIN, A STRESS COMPOUND FROM GARLIC
- Identification of Tissues Responsible for the Conjugative Metabolism of Liquiritigenin in Rats : An Analysis Based on Metabolite Kinetics
- シュウ酸ナフチドロフリル(LS121)のヒト生体内動態-2-経口投与における初回通過効果の評価
- シュウ酸ナフチドロフリル(LS121)のヒト生体内動態-1-単回静脈注入と反復静脈注入の比較
- Studies on Absorption and Excretion of Drug. XIII. The Sorption of Surface Active Agents into the Intestinal Tissue of Rat and Their Effect on the Drug Absorption in Vitro
- Decomposition of Acetylsalicylic Acid and Its Derivatives in Solid State
- Conformational Changes of Human Serum Albumin by Binding of Small Molecules
- Dissolution of Slightly Soluble Drugs. VI. Effect of Particle Size of Sulfadimethoxine on the Oral Bioavailability
- The Effect of Dosage Form on Absorption of Vitamin A into Lymph
- Solvent Effect of Dimethyl Sulfoxide on Alkaline Hydrolysis of Amide
- Studies on Absorption and Excretion of Drug. VII. A New Estimation Method for the Release of Drugs from Dosage Forms and the Availability in vivo.
- Studies on Percutaneous Absorption. III. Kinetics of Percutaneous Absorption.
- 第32回日本肝臓学会総会記録 (1) : ワークショップ (11) 肝細胞内の有機陰イオンの輸送
- A Route Dependent Bioavailability in Active Metabolite Suggested in Riboflavin-5'-Phosphate Pharmacokinetics
- Further Studies on Steroidal Glycosides from Bulbs, Roots and Leaves of Allium sativum L.
- A Furostanol Glycoside from Allium chinense G. DON
- A Furostanol Glycoside from Garlic, Bulbs of Allium sativum L.
- Steroidal Saponins from Elephant Garlic, Bulbs of Allium ampeloprasum L.
- High-Performance Liquid Chromatographic Analysis of Acidic Saponins of Ginseng and Related Plants
- STUDY OF RED GINSENG : NEW GLUCOSIDES AND A NOTE ON THE OCCURRENCE OF MALTOL
- 薬物の消化器吸収機序 (最新薬物療法manual--投薬の基本と治療プログラム) -- (薬物投与の基礎理論--PharmacokineticsとPharmacodynamics)
- HL-60細胞においてハイパーサーミアにより誘導されるアポトーシスにおけるカスパーゼ-3, 8および9経路の関与
- Pharmacokinetic Analysis on the Disappearance of Ethoxybenzamide from Plasma. Statistical Treatment of Data of Two Compartmental Model by a Digital Computer
- Studies on Absorption and Excretion of Drugs. XI. Relation between Chemical Structure and Absorption Rate. (3). Intramolecular Interaction Constant, Additivity Rule and Prediction for Intestinal Absorption Rate Coefficient
- Studies on Absorption and Excretion of Drugs. X. Relation between Chemical Structure and Absorption Rate. (2). Substituent Constant for Absorption Rate Coefficient of Foreign Organic Compounds
- Studies on Absorption and Excretion of Drugs. IX. Relation between Chemical Structure and Absorption Rate. (1). Effects of the Number and the Position of OH-Groups on the Intestinal Absorption Rate of Benzoyl Derivatives
- Studies on Absorption and Excretion of Drug. VIII. The Release Rate in vivo of Antipyretic and Analgesic Drugs from Commercial Sugar Coated Tablets.
- Studies on Absorption and Excretion of Drugs. IV. Absorption of Various Sulfonamides from the Rat Small Intestine by the Perfusion Method in vivo.
- Studies on Percutaneous Absorption. II. Effect of the Incorporated Substance.
- 癌治療への音響化学的アプローチ
- 23. 超音波照射による癌培養細胞の殺細胞效果とその増感效果