Decomposition of Acetylsalicylic Acid and Its Derivatives in Solid State
スポンサーリンク
概要
- 論文の詳細を見る
The decomposition of acetylsalicylic acid (I), acetyl-5-nitrosalicylic acid (II) and acetyl-5-chlorosalicylic acid (III) in solid state by water vapor were studied for an approach to elucidate the decomposition mechanisms of organic crystals by water vapor. All three materials showed the sigmoid-type decomposition curves and the order of the intensity of acceleration at early stage was II>III>I. From the decomposition study of pre-decomposed I and II, it was revealed that the accumulation of formed salicylic acids and/or acetic were not the cause of acceleration. Microscopic observation of advancement of reaction about II showed that the reaction starts partially on the crystals and then spread over all the crystals. It was concluded that the acceleration is attributed to the formation and growth of reaction nucleus as its wider sense. The decomposition curves were anaylzed by the empirical equation (dX/dt=(1-X)^m×k^<l+1>×t^l), where X, t, and k are the decomposition fraction, decomposition time, and the apparent decomposition rate constant, respectively, and where m and l are parameters. The apparent activation energies of decomposition of three materials were 30 kcal/mol, and the k of II linearly increases as the relative humidity rises.
- 公益社団法人日本薬学会の論文
- 1975-01-25
著者
-
長谷川 二郎
エーザイ(株)臨床研究
-
花野 学
Faculty of Pharmaceutical Sciences, University of Tokyo
-
長谷川 二郎
Faculty of Pharmaceutical Sciences, University of Chiba
-
粟津 荘司
Faculty of Pharmaceutical Sciences, University of Tokyo
-
長谷川 二郎
Faculty Of Pharmaceutical Sciences University Of Chiba:(present Address)eisai Co. Ltd.
-
長谷川 二郎
エーザイ(株)東京研究所臨床薬理
-
花野 学
Faculty Of Pharmaceutical Sciences University Of Tokyo
関連論文
- Binding of Human Epidermal Growth Factor to Tissue Homogenates of the Rat(Pharmaceutical,Chemical)
- Crystallinity and Physical Characteristics of Microcrystalline Cellulose
- The Conjugative Metabolism of 4-Methylumbelliferone and Deconjugation to the Parent Drug Examined by Isolated Perfused Liver and in Vitro Liver Homogenate of Rats
- Studies on Ligand Binding Properties of Z-Fraction from Rat Liver Cytosol using 1-Anilino-8-Naphthalenesulfonate
- Pharmacokinetic Studies of Biliary Excretion. V. The Relationship between the Biliary Excretion Behavior and the Elimination from Plasma of Xanthene Dyes and Bromsulphthalein in Rat
- Pharmacokinetic Studies of Biliary Excretion. IV. The Relationship between the Biliary Excretion Behavior and the Elimination from Plasma of Azo Dyes and Triphenylmethane Dyes in Rat
- Pharmacokinetic Study of Biliary Excretion. III. Comparison of Excretion Behavior in Xanthene Dyes, Fluorescein and Bromsulphthalein
- Pharmacokinetic Study of Biliary Excretion. II. Comparison of Excretion Behavior in Triphenylmethane Dyes
- Pharmacokinetic Studies of Biliary Excretion. I. Comparison of the Excretion Behavior in Azo Dyes and Indigo Carmine
- Pharmacokinetic Aspects of Biliary Excretion. Dose Dependency of Riboflavin in Rat
- Generalized Consideration of Administration Route Dependence of Drug Disposition and Use of Urinary Data for Prediction of the Dependence
- Biliary Excretion Behavior Difference of Quaternary Ammonium Compounds between Portal Vein and Femoral Vein Infusion in Rat
- Conjugative Metabolism of 4-Methylumbelliferone in the Rat Liver : Verification of the Sequestration Process in Multiple Indicator Dilution Experiments(Pharmaceutical,Chemical)
- Effect of Urea on Intestinal Absorption of Salicylic Acid, Benzoic Acid and Aminopyrine in Rat
- 治験環境の国際化
- Studies on Absorption and Excretion of Drugs. V. On the Mechanism of Penetration of Sulfisomezole through the Intestinal Barrier in vitro
- Studies on Absorption and Excretion of Drugs. III. Kinetics of Penetration of Sulfonamides through the Intestinal Barrier in Vitro.
- Aricept^の米国における臨床開発と日米の治験環境の違い
- タバコのバイオアベイラビリティー
- Hepatic Drug Clearance Model : Comparison among the Distributed, Parallel-Tube and Well-Stirred Models
- 200.新しい持続性テオフィリン製剤E-0686の同等性と臨床薬物動態( 抗アレルギー療法(II)新しい抗アレルギー薬)
- The Pharmacokinetic Study on the Fate of 8-Hydroxyquinoline in Rat
- A New Numerical Calculation Method for Deconvolution in Linear Compartment Analysis of Pharmacokinetics
- Kinetic Studies on Decomposition of Glutathione. III. Peptide Bond Cleavage and Desulfurization in Aqueous Solution
- Kinetic Studies on Decomposition of Glutathione. II. Anaerobic Decomposition in Aqueous Solution
- Kinetic Studies on Decomposition of Glutathione. I. Decomposition in Solid State
- Studies on Absorption and Excretion of Drugs. VI. Effects of Cations and 2,4-Dinitrophenol on the Transport of Sulfonamides through the Small Intestine of Rat
- Studies on Decomposition and Stabilization of Drugs in Solution. II. Chemical Kinetic Studies on Aqueous Solution of Methantheline Bromide.
- Pharmacokinetic Aspects of Elimination from Plasma and Distribution to Brain and Liver of Barbiturates in Rat
- Thiamine Derivatives of Disulfide Type. XIV. Kinetic Studies on the Reaction between Thiamine and Propyl Propane-Thiolsulfinate or -Thiolsulfonate
- Pharmacokinetics of Thiamine Derivatives. II. Elimination of Thiamine Derivatives from the Blood of Rat
- Pharmacokinetics of Thiamine Derivatives. I. Formation of Thiamine from Thiamine Propyl Disulfide by Erythrocytes of Rat
- Solubilization of dl-α-Tocopherol by Bile Salts, Polysorbate 80 and Egg Lecithin
- In Vivo and In Vitro Fates of 8-Hydroxyquinoline Derivatives in Rat
- Various Factors affecting Intestinal Absorption of Iodochlorhydroxyquin in Rat and Man
- Differences in Species of Iodochlorhydroxyquin Absorption, Metabolism, and Excretion
- Effects of Albumin and α_1-Acid Glycoprotein on the Transport of Imipramine and Desipramine through the Blood-Brain Barrier in Rats(Pharmaceutical)
- Relationship between the Morphological Character of 5-Nitroacetyl-salicylic Acid Crystals and the Decomposition Rate in a Humid Environment
- Identification of Tissues Responsible for the Conjugative Metabolism of Liquiritigenin in Rats : An Analysis Based on Metabolite Kinetics
- Studies on Absorption and Excretion of Drug. XIII. The Sorption of Surface Active Agents into the Intestinal Tissue of Rat and Their Effect on the Drug Absorption in Vitro
- Decomposition of Acetylsalicylic Acid and Its Derivatives in Solid State
- Conformational Changes of Human Serum Albumin by Binding of Small Molecules
- Dissolution of Slightly Soluble Drugs. VI. Effect of Particle Size of Sulfadimethoxine on the Oral Bioavailability
- The Effect of Dosage Form on Absorption of Vitamin A into Lymph
- Solvent Effect of Dimethyl Sulfoxide on Alkaline Hydrolysis of Amide
- Studies on Absorption and Excretion of Drug. VII. A New Estimation Method for the Release of Drugs from Dosage Forms and the Availability in vivo.
- Studies on Percutaneous Absorption. III. Kinetics of Percutaneous Absorption.
- Studies on Decomposition and Stabilization of Drugs in Solution. VII. Stabilization of Methantheline Bromide in Aqueous Solution by Surface-active Agents.
- A Route Dependent Bioavailability in Active Metabolite Suggested in Riboflavin-5'-Phosphate Pharmacokinetics
- Studies on Decomposition and Stabilization of Drugs in Solution. IX Stabilization of Acetylsalicylic Acid in Aqueous Solution by Surface-active Agents.
- Pharmacokinetic Analysis on the Disappearance of Ethoxybenzamide from Plasma. Statistical Treatment of Data of Two Compartmental Model by a Digital Computer
- Studies on Absorption and Excretion of Drugs. XI. Relation between Chemical Structure and Absorption Rate. (3). Intramolecular Interaction Constant, Additivity Rule and Prediction for Intestinal Absorption Rate Coefficient
- Studies on Absorption and Excretion of Drugs. X. Relation between Chemical Structure and Absorption Rate. (2). Substituent Constant for Absorption Rate Coefficient of Foreign Organic Compounds
- Studies on Absorption and Excretion of Drugs. IX. Relation between Chemical Structure and Absorption Rate. (1). Effects of the Number and the Position of OH-Groups on the Intestinal Absorption Rate of Benzoyl Derivatives
- Studies on Absorption and Excretion of Drug. VIII. The Release Rate in vivo of Antipyretic and Analgesic Drugs from Commercial Sugar Coated Tablets.
- Studies on Absorption and Excretion of Drugs. IV. Absorption of Various Sulfonamides from the Rat Small Intestine by the Perfusion Method in vivo.
- Studies on Percutaneous Absorption. II. Effect of the Incorporated Substance.