Studies on Absorption and Excretion of Drugs. X. Relation between Chemical Structure and Absorption Rate. (2). Substituent Constant for Absorption Rate Coefficient of Foreign Organic Compounds
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概要
- 論文の詳細を見る
When Danielli's model, the transition state theory and the formal treatment on the basis of the extrathermodynamic relationships were applied to the intestinal absorption of foreign organic compounds, it was expected that there should be the following relation between the absorption rate coefficients for the compound (RS) having a substituent group (S) and for the mother compound (RH). log k_<RS>/k_<RH>=constant The perfusion experiments through the small intestine of anesthetized rats for a number of benzene derivatives were carried out. The logarithmic plots of the residual ratio against the perfusion time gave straight lines and from the slopes the absorption rate coefficients were obtained. The results indicate that the values of log k_<RS>/k_<RH> for a given substituent group (S) have a proper value which is called the substituent constant.
- 公益社団法人日本薬学会の論文
- 1968-04-25
著者
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野上 寿
東京大学薬学部
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山田 秀雄
Shionogi Research Laboratories Shionogi & Co. Ltd.
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花野 学
Faculty Of Pharmaceutical Sciences University Of Tokyo
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