ラットにおけるスルピリンの投与量の代謝, 排泄速度におよぼす影響について
スポンサーリンク
概要
- 論文の詳細を見る
The effect of dose of sulpyrine on the excretion and metabolism rates was studied after the intravenous administration of sulpyrin in rat. Ten, 40 and 100 μmole/head doses were used. The excretion in urine of sulpyrine and its metabolites, 4-monomethylamino-antipyrine (I), 4-aminoantipyrine (II), 4-acetylaminoantipyrine (III), 4-hydroxyantipyrine (IV) and its conjugate (V) was examined for each dose. The differences in the time conurse with dose were studied statistically, with t-test for cumulative excretion data at each time and with F-value for the average vector of the time course. Significant differences were observed in excretion of sulpyrin, II and III for doses of 10-40 μmole and 10-100 μmole. Pharmacokinetic analyses were carried out for excretion of sulnyrin and its metabolites both for 10 and 40 μmole doses to elucidate the dose dependecy. As a result, the rate constants of elimination of sulpyrine (k_1), elimination of II (k_4), and metabolism of II other than the route to III (k_5) were found dose dependent. When the dose mcreased from 10 to 40 μmole, k_1 increased to produce a rapid excretion of sulpyrin itself, and k_4 and k_5 creased to cause a higher excretion of III. Since some discrepancy was observed, for the pharmacokinetic behaviors of IV and V, between administration of sulpyrin and IV itself, a clear kinetic analysis was not successful and dose dependency was not studied in detail.
- 公益社団法人日本薬学会の論文
- 1973-12-25
著者
関連論文
- Binding of Human Epidermal Growth Factor to Tissue Homogenates of the Rat(Pharmaceutical,Chemical)
- インドメサシンの生物薬剤学的研究(第1報) : 家兎における, 静脈内投与時の血漿中濃度の解析, および十二指腸内投与時の剤形と吸収の関連性について
- The Conjugative Metabolism of 4-Methylumbelliferone and Deconjugation to the Parent Drug Examined by Isolated Perfused Liver and in Vitro Liver Homogenate of Rats
- The Concept of "Conformation" and the "Combinatorial Approach" for Parameter Estimation in a Multi-compartment Model System
- Studies on Ligand Binding Properties of Z-Fraction from Rat Liver Cytosol using 1-Anilino-8-Naphthalenesulfonate
- Pharmacokinetic Studies of Biliary Excretion. IV. The Relationship between the Biliary Excretion Behavior and the Elimination from Plasma of Azo Dyes and Triphenylmethane Dyes in Rat
- インドメサシンの生物薬剤学的研究(第2報) : ラット小腸管吸収機構およびヒト経口投与時における微粉化製剤の利用率
- Pharmacokinetic Studies of Biliary Excretion. I. Comparison of the Excretion Behavior in Azo Dyes and Indigo Carmine
- クロラムフエニコール親水性高分子化合物共沈物の溶解性と消化管吸収
- Dose-Dependent Hepatic Handling of l-Propranolol Determined by Multiple Indicator Dilution Method : Influence of Tissue Binding of l-Propranolol on Its Hepatic Elimination
- 薬物の金魚への取り込み速度論(第3報)Salicylic Acid, Benzoic Acid, PhenolおよびPhenobarbitalの排泄
- Generalized Consideration of Administration Route Dependence of Drug Disposition and Use of Urinary Data for Prediction of the Dependence
- Biliary Excretion Behavior Difference of Quaternary Ammonium Compounds between Portal Vein and Femoral Vein Infusion in Rat
- The Influence of Glucagon on the Hepatic Transport of Taurocholate in Isolated Perfused Rat Liver : Kinetic Analysis by the Multiple Indicator Dilution Technique
- Conjugative Metabolism of 4-Methylumbelliferone in the Rat Liver : Verification of the Sequestration Process in Multiple Indicator Dilution Experiments(Pharmaceutical,Chemical)
- Infusion Rate-Dependent Positive Inotropic Action of Ouabain in Rabbits(Pharmaceutical)
- Effect of Urea on Intestinal Absorption of Salicylic Acid, Benzoic Acid and Aminopyrine in Rat
- 薬物の金魚への取込み速度論 (第2報) Benzoic Acid, Phenol Phenobarbital および Pentobarbitalの取込み
- 薬物の金魚への取り込みの速度論(第1報)水層のpH変化およびPolyethylene Glycol 6000,Urea添加によるSalicylic Acid取り込み速度への影響
- Studies on Absorption and Excretion of Drugs. V. On the Mechanism of Penetration of Sulfisomezole through the Intestinal Barrier in vitro
- Studies on Absorption and Excretion of Drugs. III. Kinetics of Penetration of Sulfonamides through the Intestinal Barrier in Vitro.
- Hepatic Drug Clearance Model : Comparison among the Distributed, Parallel-Tube and Well-Stirred Models
- 臨床医から観た剤形
- 薬学を支えた薬科機器
- Studies on Absorption and Excretion of Drugs. VI. Effects of Cations and 2,4-Dinitrophenol on the Transport of Sulfonamides through the Small Intestine of Rat
- Kinetic Evaluation of Pharmacological Effects Based on Allosteric Coupling of the Benzodiazepine/γ-Aminobutyric Acid_A Receptor in the Brain
- Kinetic Evaluation for Measurement of in Vivo Receptor Occupancy by Psychotropic Drug in Brain : Implication for Human Studies
- 日米合同薬学大会開催へ
- 医薬品の分解とその安定化(第12報)アミノアルキルエステルの構造と安定性について その4
- 医薬品の分解とその安定化(第11報)アミノアルキルエステルの構造と安定性について その3
- Thiamine Derivatives of Disulfide Type. IX. Exchange Reactions between Symmetrical Disulfide and L-Cysteine
- Disulfide形Thiamine誘導体(第10報) : Disulfide形ThiazoliumとL-Cysteineの交換反応
- 薬物相互作用に関するPharmacokinetics : 血漿中のChlorzoxazoneの濃度変化におよぼすZoxazolamineの影響
- 医薬品の分解とその安定化(第9報)アミノアルキルエステルの安定性におよぼす添加物の影響
- ラットにおけるスルピリンの吸収, 代謝, 排泄におよぼす投与経路の影響について
- ラットにおけるスルピリンの投与量の代謝, 排泄速度におよぼす影響について
- ラットにおけるスルピリンの代謝および排泄の速度論
- Pharmacokinetic Aspects of Elimination from Plasma and Distribution to Brain and Liver of Barbiturates in Rat
- Thiamine Derivatives of Disulfide Type. XIV. Kinetic Studies on the Reaction between Thiamine and Propyl Propane-Thiolsulfinate or -Thiolsulfonate
- スルピリンの吸収, 代謝, 排泄に関する速度論的研究 : 静注後のラット尿中代謝物の動態
- スルピリンの吸収, 代謝, 排泄に関する速度論的研究 (II) : 筋肉および経口投与後のラット尿中代謝物の動態
- スルピリンの吸収, 代謝, 排泄に関する速度論的研究 (I) : 静注後のラット尿中代謝物の動態
- Pharmacokinetics of Thiamine Derivatives. II. Elimination of Thiamine Derivatives from the Blood of Rat
- 医薬品の分解とその安定化(第4報) : アミノアルキルエステルの構造と安定性について その2
- 医薬品の分解とその安定化(第3報) : アミノアルキルエステルの構造と安定性について その1
- 医薬品の分解とその安定化(第2報) : 2-Diethylaminoethyl 3-Methyl-2-phenylvalerate HydrochlorideおよびMethobromideの水溶液中の安定性
- Pharmacokinetics of Thiamine Derivatives. I. Formation of Thiamine from Thiamine Propyl Disulfide by Erythrocytes of Rat
- In Vivo and In Vitro Fates of 8-Hydroxyquinoline Derivatives in Rat
- Effects of Albumin and α_1-Acid Glycoprotein on the Transport of Imipramine and Desipramine through the Blood-Brain Barrier in Rats(Pharmaceutical)
- Thiamine Derivatives of Disulfide Type. VIII. The Exchange Reaction between Thiamine Propyl Disulfide and the Various Thiols
- Thiamine Derivatives of Disulfide Type. V. Kinetic Studies of the Reaction between Thiamine Propyl Disulfide or Homologes and L-Cysteine
- Thiamine Derivatives of Disulfide Type. IV. The Exchange Reaction between Thiamine Propyl Disulfide and L-Cysteine
- Construction of a Physiologically Based Pharmacokinetic Model to Describe the Hepatobiliary Excretion Process of Ligands : Quantitative Estimation of Intracellular Diffusion
- Identification of Tissues Responsible for the Conjugative Metabolism of Liquiritigenin in Rats : An Analysis Based on Metabolite Kinetics
- Studies on Absorption and Excretion of Drug. XIII. The Sorption of Surface Active Agents into the Intestinal Tissue of Rat and Their Effect on the Drug Absorption in Vitro
- 日本薬学会奨励賞受賞杉山雄一氏の業績
- 生理学的薬物速度論, アニマルスケールアップそして薬物作用推移の予測
- オクテット
- A Route Dependent Bioavailability in Active Metabolite Suggested in Riboflavin-5'-Phosphate Pharmacokinetics
- 薬物の吸収ならびに排泄に関する研究(第12報) : サルファ剤の尿排泄に関する速度論的研究
- 「人における薬理試験の諸問題」のパネルを読んで
- 生物薬剤学の現況と将来
- 医薬品における添加剤の役割と機能
- Pharmacokinetic Analysis on the Disappearance of Ethoxybenzamide from Plasma. Statistical Treatment of Data of Two Compartmental Model by a Digital Computer
- 薬物の吸収ならびに排泄に関する研究(第16報) : ラット尿中のスルピリンならびにその代謝物の定量法
- Studies on Absorption and Excretion of Drugs. XI. Relation between Chemical Structure and Absorption Rate. (3). Intramolecular Interaction Constant, Additivity Rule and Prediction for Intestinal Absorption Rate Coefficient
- Studies on Absorption and Excretion of Drugs. X. Relation between Chemical Structure and Absorption Rate. (2). Substituent Constant for Absorption Rate Coefficient of Foreign Organic Compounds
- Studies on Absorption and Excretion of Drugs. IX. Relation between Chemical Structure and Absorption Rate. (1). Effects of the Number and the Position of OH-Groups on the Intestinal Absorption Rate of Benzoyl Derivatives
- Studies on Absorption and Excretion of Drug. VIII. The Release Rate in vivo of Antipyretic and Analgesic Drugs from Commercial Sugar Coated Tablets.
- Studies on Absorption and Excretion of Drugs. IV. Absorption of Various Sulfonamides from the Rat Small Intestine by the Perfusion Method in vivo.
- Studies on Percutaneous Absorption. II. Effect of the Incorporated Substance.
- 軟膏の研究(第1報)軟膏の経皮吸収の新測定法について
- Data analysis and evaluation of variation moments during multidrug combined therapy using delay model method.
- Relative Bioavailability of Prazosin Hydrochloride Tablet in Man
- タイトル無し
- Pharmacodynamical model of BSP, BSP glutathione bodies in rats.