薬物の吸収ならびに排泄に関する研究(第12報) : サルファ剤の尿排泄に関する速度論的研究

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概要

• 論文の詳細を見る

• The urinary excretion of nine sulfonamides were investigated in rats to compare their kinetic properties with hman. The similarity of urinary excretion rates and metabolic fates between human andhrat were observed through those sulfonamides. The dissociation constants of amino group of sulfonamide (pK_<a1>, N^4 position) were correlated to the rate constants of acetylation in body and also the final ratio between urinary excreted acetylsulfonamides and the total sulfonamides. The rate constants of original sulfonamides excreted in urine, however, did not correlate with the dissociation constants of amide group of sulfonamide (pK_<a1>, N^1-position) in a statistically significant. The kinetic study on urinary excretion of six N^1-acetylsulfonamides was also carried out in rats. The excretion rate of these acetylsulfonamides was larger than the corresponding sulfonamides. Neither the dissociation constants of acetylsulfonamides nor the excretion rate of the corresponding sulfonamides correlated to the excretion rate constants of the acetylated one. From these results, it is suggested that the excretory mechanism of acetylsulfonamides is different from that of sulfonamides.

• 公益社団法人日本薬学会の論文
• 1968-07-25

著者

• 長谷川 淳

  Faculty Of Pharmaceutical Sciences University Of Tokyo

• 花野 学

  東京大学薬学部

• 野上 寿

  東京大学薬学部

• 今岡 キク子

  共立薬科大学

• 野上 寿

  アイエスト研究所

• 長谷川 淳

  アイエスト研究所

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