ラットにおけるスルピリンの代謝および排泄の速度論
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The excretion time courses of sulpyrin and its metabolites, 4-monomethylamino-antipyrine (I), 4-aminoantipyrine (II), and 4-acetylaminoantipyrine (III), in rat urine were determined after intravenous administration of sulpyrine (10 μmole/head). Since the total recovery of sulpyrin and its metabolites from urine was about 67%, the unknown process of sulpyrin metabolism had to be presumed. With the results of excretion time courses of the metabolites after the intravenous administration of sulpyrin metabolites, I, II and III, the unknown route was regarded as the elimination of sulpyrin itself or the metabolism of II. Based on each rate constant obtained from these two pharmacokinetic model, the time courses of the amount of sulpyrin and its metabolites in rat were calculated.
- 公益社団法人日本薬学会の論文
- 1973-12-25
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