Pharmacokinetic Analysis on the Disappearance of Ethoxybenzamide from Plasma. Statistical Treatment of Data of Two Compartmental Model by a Digital Computer
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概要
- 論文の詳細を見る
The disappearance of ethoxybenzamide from a rabbit plasma after an intravenous injection was studied. 1. The distribute phase after the injection could not be neglected, and the two compartmental model was applied to analize the time course of plasma concentration. 2. The iterative least square method with a digital computer was proposed to obtain pharmacokinetic constants and their statistical values. 3. The present method gave the unique parameters independent of personal error for drawing straight lines in the semilogarithmic plots of plasma concentration vs. time, and it could test the adoptability of data for the model.
- 公益社団法人日本薬学会の論文
- 1969-10-25
著者
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野上 寿
東京大学薬学部
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花野 学
Faculty Of Pharmaceutical Sciences University Of Tokyo
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野上 寿
Faculty Of Pharmaceutical Sciences University Of Tokyo
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栗津 荘司
Faculty Of Pharmaceutical Sciences University Of Tokyo
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文 和会
Faculty of Pharmaceutical Sciences, University of Tokyo
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文 和会
Faculty Of Pharmaceutical Sciences University Of Tokyo
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