Studies on Absorption and Excretion of Drugs. IV. Absorption of Various Sulfonamides from the Rat Small Intestine by the Perfusion Method in vivo.

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1. While the isotonic phosphate buffer (pH 6.0〜6.4) was recirculatingly perfused through the rat small intestine for 3 hours, volume of the solution was constant. 2. When the isotonic phosphate buffered solution (pH 6.0〜6.4) containing sulfonamide was recirculatingly perfused through the rat small intestine in vivo, the logarithm of residual ratio of the drug vs. time curve was a straight line. 3. From the slope of the straight line, apparent permeability coefficient, p_a, was obtained. The constants were : Sulfaguanidine (0.0×10^<-3> cm./min.) ; Sulfathiazole (0.9×10^<-3>) ; Sulfanilamide (1.0×10^<-3>) ; Sulfamethoxypyridazine (1.7×10^<-3>) ; Sulfisomezole 3.2×10^<-3>). 4. It may be suggested that the permeability coefficient of sulfisomezole from intestinal lumen (isotonic phosphate buffered solution at pH 6.0〜6.4) into plasma is much larger than that from plasma into intestinal lumen. 5. The P_a-pH diagrams of four sulfonamides were obtained.
公益社団法人日本薬学会の論文
1963-03-25