Thiamine Derivatives of Disulfide Type. IX. Exchange Reactions between Symmetrical Disulfide and L-Cysteine
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概要
- 論文の詳細を見る
Kinetic studies were made about the exchange reactions between dibenzyl disulfide (I) and cysteine, and between diphenyl disulfide (III) and cysteine, in order to determine the dependence on the reaction rates of the structures of disulfides and of thiols. It was demonstrated that the greater the pK_a of the thiols or the smaller the pK_a of the leaving molecule from disulfides, the greater are the rate constants. It was also shown that these exchange reactions stood in equilibria. Being compared this with the reactions between thiamine derivatives of disulfide type and thils where reverse reaction does not proceed, it may be concluded that the absence of reverse reaction is due to the thiamine's behavior in aqueous solution that the thioaniontype structure readily turn to thiazolium-type one below neutral pH.
- 公益社団法人日本薬学会の論文
- 1970-06-25
著者
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長谷川 淳
Faculty Of Pharmaceutical Sciences University Of Tokyo
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安藤 恭子
Grelan Pharmaceutical Co. Ltd.
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野上 寿
東京大学薬学部
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野上 寿
Faculty of Pharmaceutical Sciences, University of Tokyo
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竹内 嘉智子
グレラン製薬株式会社研究部
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長谷川 淳
Pharmaceutical Development, Ayerst Laboratories, Inc.
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野上 寿
Faculty Of Pharmaceutical Sciences University Of Tokyo
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五十里 紀子
グレラン製薬株式会社研究部
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