医薬品の分解とその安定化(第8報)ノルフェニレフリンと糖類分解物との反応成績体

概要

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A marked coloration was recognized on the surface of sugar-coated tablet of norphenylephrine (I) hydrochloride when it was stored in an oven for 24 hr at 80°. This browning also took place on heating of I hydrochloride with sugar. It was assumed that isoquinoline derivatives produced from I and decomposition products of sugar, 5-hydroxymethyl-furfural (II) and levulinic acid (V), would be detected in the reaction mixture of I and glucose. Phenolic cyclisation of an ethanolic solution of I and II or V gave isoquinoline derivative, 4,6-dihydroxy-1-(4-hydroxymethyl-1-furanyl)-1,2,3,4 -tetrahydroisoquinoline (III) or 6,8-dihydroxy-10b-methyl-1,2,5,6-tetrahydropyrrolo[2,1-α]isoquinoline-3[2H]-one (VI). The presence of III and VI in the discolored reaction mixture of I and glucose was presumed from thin-layer chromatographic result.
社団法人日本薬学会の論文
1973-07-25