固形剤の物性に関する製剤学的研究(第3報)錠剤の組成および形状のおよぼす内部強度分布について

概要

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In order to examine the influence of tablet formula and tablet shape on the distribution of hardness inside a tablet, the hardness inside each tablet was measured by using a boring hardness measuring apparatus. The sample tablets with ingredients used in general, lactose and crystalline cellulose, of different formula were formed in the plane and convex type by using an ordinary tableting machine. Measurement of the hardness inside various tablets gave curves for the distribution of hardness, in which compressibility by the difference in the ratio of ingredients was observed as a marked difference in the distribution of hardness inside each tablet. As to the distribution of hardness by the difference in the tablet shape, in the case of convex type, the smaller the radius of curvature, the larger was the difference in the distribution of hardness in each layer and, in the case of the tablet with ingredients of poor compressibility, the tablet shape had a larger effect on the distribution of hardness. It was found that the presence and position of a capping can be confirmed from the distribution of hardness.
1975-07-25