フェニルアシレートとアミドのアシル基交換反応(第2報)p-ニトロフェニルアシレートとベンズアミドのアシル基交換反応

概要

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The general acylation of aromatic amides with substituted phenyl acylates was studied. Amides, i.e. benzamide or ethenzamide, were allowed to react with various p-nitrophenyl acylates (acyl moiety ; CH_3CH_2CO, CH_3 (CH_2)_2CO, (CH_3)_2CHCO, CH_3 (CH_2)_3CO, (CH_3)_3CCO, CH_3 (CH_2)_4CO, CH_3 (CH_2)_10CO, CICH_2CO, PhCH_2CO, PhCO, p-NO_2-PhCO, 2-C_4H_3OCO) either in the molten state or in xylene. It was found that benzamide and ethenzamide were acylated with p-nitrophenyl acylates, and that the acidity of the corresponding carboxylic acid with acyl moiety reflects on the yield of imides, although the transacylation of aromatic acylate was generally slower than that of aliphatic acylate.
社団法人日本薬学会の論文
1983-11-25