固形剤の物性に関する製剤学的研究(第2報)錠剤内強度分布の測定

概要

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A boring-hardness measurement apparatus makes it possible to accurately measure the hardness of various layers inside a tablet which has been difficult in the past. The hardness and position of each layer of a multi-layered tablet can be measured by the boring speed, from the point of inflections of the boring speed curve. In the case of multi-compressed tablets, it is possible to measure the hardness and thickness of the outer layer and the core of the tablet, and to detect compressive deformations, breakages, and changes in the hardness of the core after a final compression. In the case of a sugar-coated tablet, it is possible to measure changes in the hardness of the sugar-coat layer and the core, and of the core before and after coating, as well as changes due to sugar-coat formulations and ageing. Furthermore, it is possible to measure the distribution of hardness inside the tablet, and to detect the presence of capping, lamination etc.
1974-10-25