医薬品の生物薬剤学的研究(第6報)o-EthoxybenzamideとN-(β-Hydroxybutyryl)-p-phenetidineの家兎血清中濃度におよぼす2-Bromo-isovalerylureaの併用効果

概要

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The concentrations of o-ethoxybenzamide (EBA), N-(β-hydroxybutyryl)-p-phenetidine (HBP) and metabolites in the rabbit serum were investigated when EBA or HBP was administered orally with 2-bromo-isovalerylurea (BVU). 1) The concentration of EBA in the serum increased when 100 mg/kg of EBA was administered concurrently with 40 mg/kg of BVU as compared with the administration of 100 mg/kg of EBA alone. The con-administration of EBA and BVU also decreased the concentration of salicylamide (SAM) sulfate in the serum. 2) The concentration of HBP in the serum increased when 100 mg/kg of HBP and 40 mg/kg of BVU were administered together, while that of N-(β-hydroxybutyryl)-p-aminophenol (HBA) glucuronide decreased. 3) The concentrations of EBA and HBP in the serum increased when 100 mg/kg of EBA, 28.5 mg/kg of HBP and 45.5 mg/kg of BVU were administered together as compared with the co-administration of 100 mg/kg of EBA and 28.5 mg/kg of HBP, while those of SAM sulfate and HBA glucuronide decreased. 4) The deethylation of EBA and HBP was inhibited non-competitively by the addition of BVU in 9000×g supernatant fraction of the rabbit liver.
社団法人日本薬学会の論文
1983-05-25