固形剤の物性に関する製剤学的研究(第1報)固形剤穿孔強度の測定法

概要

論文の詳細を見る
A new apparatus makes it possible to measure accurately the hardness inside solid form drugs. This apparatus tests the hardness by measuring the boring speed of a constantly rotating drill pit at constant pressure through a solid sample. Tests on crystals of constant hardness such as potassium bromide, sodium thiosulfate, and sucrose with this apparatus gave a constant boring speed under constant pressure of each crystal according to its hardness. When tablets of different hardness were measured, the boring speed corresponded to the hardness of each tablet. Moreover, it is possible to measure the minimum pressure necessary to bore into a solid sample as a test of its hardness. These results demonstrated that the hardness inside solid form drugs may be accruately and continuously measured by this method.
1974-10-25