Thiamine Derivatives of Disulfide Type. XII. Kinetic Studies on the Reaction between Propyl Propane-Thiolsulfinate or -Thiolsulfonate and Cysteine
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概要
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The kinetic studies were conducted on the reaction between propyl propane-thiol-sulfinate (PrSSOPr) or -thiolsulfonate (PrSSO_2Pr) and 1-cysteine. The reactions were shown by the following equations. PrSSOPr+CySH→CySSPr+(PrSOH) 2(PrSOH)→PrSSOPr+H_2O and PrSSO_2Pr+CySH→CySSPr+PrSO_2H The studies were carriepd out at an acidic pH because of the very fast rates of these reactions. The reaction species of cysteine was proved to be the protonated S-anion, RN^+H_3・S-. The values of the enthalpy of activation and the entropy of activation were calculated to be 8.4 kcal/mole, -15.1 e.u. for PrSSOPr and 2.9 kcal/mole, -19.2 e. u. for PrSSO_2Pr.
- 公益社団法人日本薬学会の論文
- 1971-12-25
著者
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長谷川 淳
Faculty Of Pharmaceutical Sciences University Of Tokyo
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野上 寿
Faculty of Pharmaceutical Sciences, University of Tokyo
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青木 勝夫
Technological Research Laboratories, Research and Development Division, Takeda Chemical Industries,
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野上 寿
Faculty Of Pharmaceutical Sciences University Of Tokyo
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青木 勝夫
Pharmacy Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.
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青木 勝夫
Pharmacy Research Laboratories Research And Development Division Takeda Chemical Industries Ltd.
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