Studies on Powdered Preparations. II. Studies on Tablet Disintegration of Calcium Carbonate by Thermal Analysis.
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概要
- 論文の詳細を見る
A new mothod for examining the disintegration of a tablet and a granule continuously and in detail was proposed. The beginning of disintegration, the time necessary for the maximum surface area of tablet ingredient, and the time required for a powder to dissolve completely were determined precisely. This method was applied to the tablet of calcium carbonate in the acetate buffer of pH 4.2 and the following conclusions were drawn. a) The tablet prepared from CaCO_3 powder by direct compression disintegrated and dissolved very rapidly, and difference between the original powder and the tablet was not recognized. b) The disintegration and solution rate of CaCO_3 granule that contained starch paste was not rapid and larger particles remained undissolved in the final stage. c) It was evidenced that the tablet prepared from CaCO_3 granule disintegreted more slowly than the tablet prepared by direct compression.
- 公益社団法人日本薬学会の論文
- 1959-05-10
著者
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長谷川 淳
Faculty Of Pharmaceutical Sciences University Of Tokyo
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野上 寿
Faculty Of Pharmaceutical Sciences University Of Tokyo
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仲井 由宜
Faculty Of Pharmaceutical Sciences University Of Tokyo
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