Studies on Decomposition and Stabilization of Drugs in Solution. XX. Hydrolysis of Acylcholine
スポンサーリンク
概要
- 論文の詳細を見る
Hydrolysis of acylcholines in 0.1N hydrochloric acid solution and that in borate buffer solution [Na_2B_4O_7 (0.01M)+H_3BO_3 (0.16M)+NaCl (0.04M)] at 60° were studied. Hydrolysis in Acidic Solution-Octanoylcholine iodide, decanoylcholine iodide, dodecanoylcholine iodide and hexadecanoylcholine iodide (micellar acylcholines) were less stable below their critical micelle concentrations (CMC) and more stable above their CMC. Acylcholine with longer hydrocarbon chain was more stable than shorter chain. Hydrolysis in Basic Solution-Linear relationship was found between concentration (log scale) of acylcholine and time on hydrolysis at its low concentration (below CMC) but was not found at its high concentration (above CMC). But it might be considered that initial stage was linear. The linear portion at initial stage and the gradually curved portion with course of time were discussed. (1) The linear portion at initial stage Hydrolysis was accelerated by formation of micelle and it was observed that the longer the hydrocarbon chain was, the less the stability became. (2) The gradually curved portion with course of time It was considered that fatty acid produced by hydrolysis of acylcholine in borate buffer solution was ionic type and it formed complex with cationic acylcholine, and repression of hydrolysis was ascribed to solubilization of this complex into micelle of acylcholine.
- 公益社団法人日本薬学会の論文
- 1969-10-25
著者
-
野上 寿
Faculty of Pharmaceutical Sciences, University of Tokyo
-
金久保 好男
Hospital Pharmacy Niigata University
-
野上 寿
Faculty Of Pharmaceutical Sciences University Of Tokyo
関連論文
- Pharmacokinetic Studies of Biliary Excretion. V. The Relationship between the Biliary Excretion Behavior and the Elimination from Plasma of Xanthene Dyes and Bromsulphthalein in Rat
- Pharmacokinetic Studies of Biliary Excretion. IV. The Relationship between the Biliary Excretion Behavior and the Elimination from Plasma of Azo Dyes and Triphenylmethane Dyes in Rat
- Pharmacokinetic Study of Biliary Excretion. III. Comparison of Excretion Behavior in Xanthene Dyes, Fluorescein and Bromsulphthalein
- Pharmacokinetic Study of Biliary Excretion. II. Comparison of Excretion Behavior in Triphenylmethane Dyes
- Pharmacokinetic Studies of Biliary Excretion. I. Comparison of the Excretion Behavior in Azo Dyes and Indigo Carmine
- Studies on Tablet Disintegration. I. The Effect of Penetrating Rate on Tablet Disintegration.
- Studies on Powdered Preparations. XIX. Dissolution Kinetics of Benzoic Acid Derivatives
- Studies on Absorption and Excretion of Drugs. V. On the Mechanism of Penetration of Sulfisomezole through the Intestinal Barrier in vitro
- Studies on Absorption and Excretion of Drugs. III. Kinetics of Penetration of Sulfonamides through the Intestinal Barrier in Vitro.
- Adsorption of Benzoic Acid Derivatives by Carbon Black from Aqueous Solution and Related Phenomena
- Adsorption of Local Anesthetics from Aqueous Solution. Analysis of Factors Affecting the Nerve Blocking
- Model Barrier Affecting Drug Transport
- Dissolution Kinetics of Barbital Polymorphs
- Dissolution Kinetics of Polyvinylpyrrolidone of Various Molecular Weights
- Studies on Absorption and Excretion of Drugs. VI. Effects of Cations and 2,4-Dinitrophenol on the Transport of Sulfonamides through the Small Intestine of Rat
- Studies on Decomposition and Stabilization of Drugs in Solution. XX. Hydrolysis of Acylcholine
- Studies on Decomposition and Stabilization of Drugs in Solution. XIX. Critical Micelle Concentration of Acylcholine
- Studies on Decomposition and Stabilization of Drugs in Solution. XV. Hydrolysis of Sodium Octyl, Myristyl, Cetyl, and Pentadecane-8-sulfates.
- Studies on Decomposition and Stabilization of Drugs in Solution. XIII. On Sodium Lauryl Sulfate.
- Studies on Decomposition and Stabilization of Drugs in Solution. II. Chemical Kinetic Studies on Aqueous Solution of Methantheline Bromide.
- Adsorption of Phenothiazines from Aqueous Solution. Approach to Understanding of Membrane Action
- Thiamine Derivatives of Disulfide Type. IX. Exchange Reactions between Symmetrical Disulfide and L-Cysteine
- Complexes of Polyethylene Oxide with Guanidine Hydrochloride and with Phenobarbital. Preliminary Structural Studies by Differential Scanning Calorimetry, Polarized Infrared Spectroscopy and X-Ray Fiber Photography
- Pharmacokinetic Aspects of Elimination from Plasma and Distribution to Brain and Liver of Barbiturates in Rat
- Thiamine Derivatives of Disulfide Type. XIV. Kinetic Studies on the Reaction between Thiamine and Propyl Propane-Thiolsulfinate or -Thiolsulfonate
- Pharmacokinetics of Thiamine Derivatives. II. Elimination of Thiamine Derivatives from the Blood of Rat
- Pharmacokinetics of Thiamine Derivatives. I. Formation of Thiamine from Thiamine Propyl Disulfide by Erythrocytes of Rat
- Thiamine Derivatives of Disulfide Type. V. Kinetic Studies of the Reaction between Thiamine Propyl Disulfide or Homologes and L-Cysteine
- Thiamine Derivatives of Disulfide Type. IV. The Exchange Reaction between Thiamine Propyl Disulfide and L-Cysteine
- Physico-chemical Approach to Biopharmaceutical Phenomena. V. Relationship between the Adsorption by Carbon Black from Aqueous Solution and the Biopharmaceutical Data of Barbituric Acid Derivatives
- Physico-chemical Approach to Biopharmaceutical Phenomena. IV. Adsorption of Barbituric Acid Derivatives by Carbon Black from Aqueous Solution
- Studies on Powdered Preparations. XIV. Wetting of Powder Bed and Disintegration Time of Tablet
- Factors Affecting Dissolution Rate of Cellulose Acetate Phthalate in Aqueous Solution
- Thiamine Derivatives of Disulfide Type. III. Enzyme Systems in Rat Intestine contributed for Thiamine Formation from the Disulfide Type Derivatives
- Thiamine Derivatives of Disulfide Type. II. The Formation of Thiamine from the Disulfide Derivatives in Rat Intestine in Vitro
- Thiamine Derivatives of Disulfide Type. I. Formation of Thiamine from Thiamine Propyl Disulfide in Rat Intestine in Vitro
- Studies on Decomposition and Stabilization of Drugs in Solution. XVIII. The Hydrolysis of Phthalylsulfathiazole
- Thiamine Derivatives of Disulfide Type. XV. The Ring Opening-closing Reactions of 4-Methylthiazolium Salts
- Binding of 1-Anilino-8-naphthalenesulfonate to Polyvinylpyrrolidone, Poly-N-vinyl-2-oxazolidone, Poly-N-vinyl-5-methyl-2-oxazolidone and Polyethylene Glycol-20M in Aqueous Solution
- Thiamine Derivatives of Disulfide Type. XI. Oxidation of Dipropyl Disulfide with Hydrogen Peroxide and Properties of the Products
- Thiamine Derivatives of Disulfide Type. XIII. Kinetic Studies on the Degradation of Propyl Propanethiolsulfonate by Hydroxyl Ion
- Thiamine Derivatives of Disulfide Type. XII. Kinetic Studies on the Reaction between Propyl Propane-Thiolsulfinate or -Thiolsulfonate and Cysteine
- Mechanism of Adsorption of Phenols by Carbon Black from Aqueous Solution
- Molecular Sizes of Phenothiazines taken upon the Adsorption from Aqueous Solution and upon the Permeation through Cellulose Membrane
- Permeation of Phenothiazines through Cellulose Membrane
- Analysis of Solubility Properties of L-Tryptophan in Aqueous Solution based on the Effects of Third Component on Optical Rotatory Dispersion and on Adsorption by Carbon Black
- The Stabilization Mechanism of Acylcholinesters in Aqueous Solution by Sodium Lauryl Sulfate
- Studies on Absorption and Excretion of Drug. XIII. The Sorption of Surface Active Agents into the Intestinal Tissue of Rat and Their Effect on the Drug Absorption in Vitro
- Dissolution Phenomena of Organic Medicinals involving Simultaneous Phase Changes
- Binding of 1-Anilinonaphthalene-8-sulfonate to Water Soluble Synthetic Polymers
- Studies on Decomposition and Stabilization of Drugs in Solution. VII. Stabilization of Methantheline Bromide in Aqueous Solution by Surface-active Agents.
- Studies on Powdered Preparations. XVIII. Dissolution Rate of Sulfadiazine in Various Aqueous Solutions.
- Studies on Powdered Preparations. XVII. Dissolution Rate of Sulfonamides by Rotating Disk Method
- Studies on Powdered Preparations. XVI. Aging of Dried Aluminum Hyodroxide Gel in Aqueous Ammonia
- Studies on Powdered Preparations. XV. Aging of Dried Aluminum Hydroxide Gel under Humidity and in Water
- Studies on Powdered Preparations. XIII. Reaction between Dried Aluminum Hydroxide Gel and Organic Acid
- Studies on Powdered Preparations. IX. Thermal Analysis of the Velocity of Reaction between Dried Aluminum Hydroxide Gel and Acid.
- Thiamine Derivatives of Disulfide Type. VII. Kinetics between Thiamine Tetrahydrofurfuryl Disulfide and L-Cysteine or Its Derivatives
- Thiamine Derivatives of Disulfide Type. VI. Kinetic Studies of the Thiol-Exchange Reaction between Thiamine Disulfide and L-Cysteine
- Studies on Powdered Preparations. XX. Disintegration of the Aspirin Tablets containing Starches as Disintegrating Agent
- Studies on Decomposition and Stabilization of Drugs in Solution. III. Chemical Kinetic Studies on Aqueous Solution of 2-Diethylaminoethyl Diphenylglycolate Methobromide
- Studies on Powdered Preparations. III. Studies on Disintegration of Basic Magnesium Carbonate Tablet.
- Studies on Powdered Preparations. II. Studies on Tablet Disintegration of Calcium Carbonate by Thermal Analysis.
- Studies on Absorption and Excretion of Drugs. II. Kinetics of Penetration of Basic Drug, Aminopyrine, through the Intestinal Barrier in vitro.
- Studies on Absorption and Excretion of Drugs. I. Kinetics of Penetration of Acidic Drug, Salicylic Acid, through the Intestinal Barrier in vitro.
- Studies on Decomposition and Stabilization of Drugs in Solution. IX Stabilization of Acetylsalicylic Acid in Aqueous Solution by Surface-active Agents.
- Pharmacokinetic Analysis on the Disappearance of Ethoxybenzamide from Plasma. Statistical Treatment of Data of Two Compartmental Model by a Digital Computer
- Studies on Absorption and Excretion of Drug. VIII. The Release Rate in vivo of Antipyretic and Analgesic Drugs from Commercial Sugar Coated Tablets.
- Studies on Absorption and Excretion of Drugs. IV. Absorption of Various Sulfonamides from the Rat Small Intestine by the Perfusion Method in vivo.
- Studies on Percutaneous Absorption. II. Effect of the Incorporated Substance.