Complexes of Polyethylene Oxide with Guanidine Hydrochloride and with Phenobarbital. Preliminary Structural Studies by Differential Scanning Calorimetry, Polarized Infrared Spectroscopy and X-Ray Fiber Photography
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概要
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The complexes of polyethylene oxide (PEO) with guanidine hydrochloride and with phenobarbital were subjected to differential scanning calorimetry (DSC), polarized infrared (IR) spectroscopy and X-ray fiber photography, confirming the formations of the complexes and discussing the structures of PEO molecules in the complexes in comparison with PEO-urea complex or original samples of PEO. The formations of the complexes of PEO with urea, with guanidine hydrochloride and with phenobarbital were confirmed by DSC curves of physical mixtures of the respective original components. It may be concluded on the basis of the results by X-ray fiber photography that the three dimentional structure regarding the fiber identity period are different among ordinary PEO, PEO-guanidine hydrochloride complex and PEO-phenobarbital complex. The polarized IR spectroscopy informed that PEO molecule in PEO-guanidine hydrochloride complex may have a structure not so different from the 7_2 helix in the ordinary PEO. It was assumed that PEO molecule in PEO-phenobarbital complex is more distorted than that in PEO-guanidine hydrochloride complex in comparison with intact one, as the fiber identity period was considered to consist of one chemical unit.
- 公益社団法人日本薬学会の論文
- 1974-01-25
著者
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永井 恒司
Department of Pharmaceutics, Hoshi University
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永井 恒司
Research Center Taisho Pharmaceutical Co. Ltd.
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野上 寿
Faculty of Pharmaceutical Sciences, University of Tokyo
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河野 健治
Kyorin Chemical Laboratory
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永井 恒司
Hoshi Institute of Pharmaceutical Sciences
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野上 寿
Faculty Of Pharmaceutical Sciences University Of Tokyo
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