Permeation of Diclofenac Salts through Silicone Membrane : a Mechanistic Study of Percutaneous Absorption of Ionizable Drugs
スポンサーリンク
概要
- 論文の詳細を見る
To understand the mechanism of percutaneous absorption of ionizable drugs, diclofenac salts (DM : M=Li, Na, K, NH_4,N(Me)_4) as hydrophilic drugs were compared to free diclofenac acid (DH), a hydrophobic drug. DNa showed the highest permeability coefficient among DMs. The experimental diffusion coefficient through the silicone membrane (Dm) was compared with the calculated diffusion coefficient for an ion pair molecule (Dm_<pair>) of DM.This may suggest that the existence of the lipid pathway of the DMs is the same as the DH.
- 社団法人日本薬学会の論文
- 1994-06-15
著者
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永井 恒司
Department of Pharmaceutics, Hoshi University
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永井 恒司
星薬科大学医薬品化学研究所
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米谷 芳枝
Department of Pharmaceutics, Hoshi University
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久郷 美穂
Department of Pharmaceutics, University of Hoshi
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米谷 芳枝
星薬科大学
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久郷 美穂
Department Of Pharmaceutics University Of Hoshi
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