Morphologic Examination of Rabbit Nasal Mucosa after the Nasal Administration of Insulin Peanut Oil Suspension and a Powder Dosage Form with Soybean-Derived Sterylglucoside
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概要
- 論文の詳細を見る
Soybean-derived sterylglucoside mixture (SG) is a potentially effective absorption enhancer for the nasal absorption of insulin. Insulin in a peanut oil suspension dosage form and in a powder dosage form with SG were administered into the rabbit nasal cavity. After 0.5 or 1h, nasal mucosa was taken from the nasal cavity and side effects were examined by an optiphoto light microscope. The insulin in the peanut oil suspension produced a histological change in the nasal epithelium mucosae, as well as mucodermal phlogistic cellular infiltration. The peanut oil suspension with SG showed side effects slightly stronger than without SG. SG alone and the insulin powder dosage form with SG produced no signs of inflammation, erosion or squamous metaplasia. The results from this study indicate that SG can be considered safe.
- 社団法人日本薬学会の論文
- 1995-06-15
著者
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永井 恒司
Department of Pharmaceutics, Hoshi University
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永井 恒司
星薬科大学医薬品化学研究所
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山本 知永
星薬大
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山本 知永
Department of Pharmaceutics, Hoshi University
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米谷 芳枝
Department of Pharmaceutics, Hoshi University
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磯和 弘一
The Center of Japan Biological Chemistry Co., Ltd.
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磯和 弘一
株式会社 日本生物化学センター 岐阜研究所
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磯和 弘一
日本生物化学センター
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米谷 芳枝
星薬科大学
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Isowa Koichi
The Center Of Japan Biological Chemistry Co. Lte.
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