Accelerated Degradation of Non-steroid Anti-inflammatory Drugs at Carbon Black/Water Interface

概要

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In the course of investigating the adsorption of non-steroid anti-inflammatory drugs at carbon black (CB)/water interface, it was found that the degradation of some of these drugs was accelerated. It was also found that this acceleration was observed in the existense of graphite in the place of CB, but not observed in a simple aqueous solution nor in the presence of such hydrophilic powder as silica gel. The results obtained from solutions of different pH and temperature showed that the Rf values of thin-layer chromatography of the degradation products of the respective drugs were coincident to both cases of the presence of CB at 30°and the absence of CB at 60°, while the rate of degradation was observed greater in the presence of CB than in the absence of CB.
社団法人日本薬学会の論文
1975-02-25