Microencapsulation and Bioavaliability in Beagle Dogs of Indomethacin
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概要
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Indomethacin (IMC) suspended in soybean oil was microencapsulated in a gelatinacacia system by a modified phase separation method from aqueous solution. The microcapsules were hardened with formaldehyde without the use of sodium hydroxide. Average particle diameter of the microcapsules was 111μm, and the content of IMC in the microcapsules was more than 80% of the initial amount of IMC. The in vitro dissolution of IMC from the microcapsules was slower than that of intact IMC, and this indicated that the walls of the microcapsules affected the drug dissolution. The bioavailabilities in beagle dogs of the IMC microcapsules and of a soybean oil suspension of IMC administered in capsules were larger than that of intact IMC.
- 1981-01-25
著者
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永井 恒司
Hoshi Institute of Pharmaceutical Sciences
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南部 直樹
Hoshi Institute of Pharmaceutical Sciences
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武田 豊
Hoshi Institute Of Pharmaceutical Sciences
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