Relationship between Competitive Adsorption by Carbon Black from Aqueous Solution and Formation of Molecular Compounds in the Solid Phase for Aminopyrine and Barbituric Acid Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
As an approach to an understanding of the combined effects of drugs, the competitive adsorption of aminopyrine (AM) and barbituric acid derivatives (BA) by carbon black (CB) from aqueous solution was investigated in relation to the formation of molecular compounds between AM and BA. The formation of molecular compounds of AM with various BA compounds was confirmed by differential scanning calorimetry (DSC), powder X-ray diffractometry and infrared absorption spectrometry. All adsorption isotherms of AM and BA were in good accordance with Langmuir's equation. From the results of perturbation experiments (20°to 40°transition), it was considered that the mechnaisms of adsorption of AM and BA by CB were "chemisorption" and "physical adsorption, " respectively. In competitive adsorption, the decrease of BA adsorbed was larger for compounds that formed molecular compounds with AM than for those that did not. It was considered that adsorption was influenced by an interaction between AM and BA molecules at the surface of CB ; the greatest effect in competitive adsorption was seen with AM and barbital, which also formed a molecular compound most readily.
- 公益社団法人日本薬学会の論文
- 1980-02-25
著者
-
上田 晴久
星薬科大学
-
永井 恒司
Hoshi Institute of Pharmaceutical Sciences
-
南部 直樹
Hoshi Institute of Pharmaceutical Sciences
-
上田 晴久
Hoshi Institute of Pharmaceutical Sciences
-
大倉 輝明
Hoshi Institute Of Pharmaceutical Sciences
関連論文
- P-60 シクロデキストリンを応用したヨウ素溶液の検討
- WII-11 Targeting Cancer Chemotherapy : 活性炭及びア***ジール吸着ペプレオマイシンの治療効果に関する基礎的研究(第31回日本消化器外科学会総会)
- Accelerated Degradation of Non-steroid Anti-inflammatory Drugs at Carbon Black/Water Interface
- Adsorption from Solution, Permeation through Cellulose Membrane, Partition Coefficient and Surface Tension of Several Antidepressants and Phenothiazines
- Adsorption of Phenothiazines from Aqueous Solution by Aerosil
- Preparation and Phase II Clinical Examination of Topical Dosage Form for Treatment of Carcinoma Colli Containing Bleomycin with Hydroxypropyl Cellulose
- 界面培養表皮細胞を通してのイヌリンおよび数種の薬物の経皮吸収
- Inclusion Complexes of Cinnarizine with β-Cyclodextrin in Aqueous Solution and in the Solid State
- 176 活性炭吸着抗癌剤の基礎実験 : 第1報(第29回日本消化器外科学会総会)
- Dissolution Behavior of Flufenamic Acid dispersed in Cross-linked Insoluble Polyvinylpyrrolidone : Effect of Water-soluble Polymers added as the Third Component
- Stability and Several Physical Properties of Amorphous and Crystalline Forms of Indomethacin
- Nuclear Magnetic Resonance Study of the Binding of Tolbutamide and Chlorpropamide to Bovine Serum Albumin
- Dissolution Profile and Bioavailability of Sulfamonomethoxine/18-Crown-6 Complex in Comparison with Sulfamonomethoxine Anhydrate and Hydrate
- Apparent Oral Toxicity of 18-Crown-6 in Dogs
- アラビアゴムで乳化したO/Wエマルションの濁度比法による研究
- Analysis of Factors affecting Dissolution of Digoxin from Tablets
- Factors affecting the Adsorption of Chlorhexidine Gluconate by Hydroxyapatite
- Effect of β-Cyclodextrin on the Degradation Rate of Amoxicillin in Acidic Solution
- Directly Compressed Tablets containing Water-insoluble Glucan and Microcrystalline Cellulose in Addition to Lactose
- Dissolution Behavior of Chlorpropamide Polymorphs
- Relationship between Competitive Adsorption by Carbon Black from Aqueous Solution and Formation of Molecular Compounds in the Solid Phase for Aminopyrine and Barbituric Acid Derivatives
- The Acid-Base Equilibrium Reaction of Benzodiazepinooxazoles
- Absorption of Salicylic Acid through the Oral Mucous Membrane of Hamster Cheek Pouch
- Permeation of Drug through a Model Membrane consisting of Millipore Filter with Oil
- Complexes of Polyethylene Oxide with Guanidine Hydrochloride and with Phenobarbital. Preliminary Structural Studies by Differential Scanning Calorimetry, Polarized Infrared Spectroscopy and X-Ray Fiber Photography
- Polymorphism of Phenylbutazone
- Preparation and Phase II Clinical Examination of Topical Dosage Forms for the Treatment of Carcinoma Colli Containing Bleomycin, Carboquone, or 5-Fluorouracil with Hydroxypropyl Cellulose
- Interaction of Phenothiazines with Pectin in the Solid State
- Interaction of Phenothiazines with Pectin in Aqueous Solution
- New Procedure for Assay of Lactobacilli using the Luciferin-Luciferase System
- Interaction of Several Nonsteroidal Antiinflammatory Drugs with Pectin in Aqueous Solution and in Solid State
- Influence of Inclusion of Nonsteroidal Antiinflammatory Drugs with β-Cyclodextrin on the Irritation to Stomach of Rats upon Oral Administration
- Bioavailability of Powdered Inclusion Compounds of Nonsteroidal Antiinflammatory Drugs with β-Cyclodextrin in Rabbits and Dogs
- Interactions of α- and β-Cyclodextrin with Several Non-Steroidal Antiinflammatory Drugs in Aqueous Solution
- Complexation of Several Drugs with Water-Soluble Cyclodextrin Polymer(Pharmaceutical)
- Thermodynamic Properties of Polymorphs of Tolbutamide
- Solid-State Nuclear Magnetic Resonance Spectroscopy and Raman Spectroscopy of the Inclusion Compound of Tolbutamide with β-Cyclodextrin
- Permeation of Sulfonylureas through Cellulose and Dimethylpolysiloxane Membranes
- Adsorption of Benzothiadiazines by Carbon Black from Aqueous Solution, and Related Phenomena
- Nuclear Magnetic Resonance (NMR) Spectroscopy of Inclusion Compounds of Tolbutamide and Chlorpropamide with β-Cyclodextrin in Aqueous Solution
- Adsorption of Sulphonylureas by Carbon Black from Aqueous Solution
- Enhancement of Dissolution Properties of Griseofulvin from Ground Mixtures with Chitin or Chitosan
- Permeation of Drugs through Chitosan Membranes
- Directly Compressed Tablets containing Chitin or Chitosan in Addition to Lactose or Potato Starch
- Factors Affecting the Dissolution of Ketoprofen from Solid Dispersions in Various Water-soluble Polymers
- Mucosal Dosage Form of Lidocaine for Toothache using Hydroxypropyl Cellulose and Carbopol
- Factors affecting the Dissolution of Indomethacin dispersed in Various Water-Soluble Polymers
- Analysis of Interfacial Transfer of Indomethacin following Dissolution of Indomethacin/Polyvinylpyrrolidone Coprecipitates
- Adsorption of Nicotinic and Isonicotinic Acid Derivatives by Hydroxyapatite from Aqueous Solutions
- New Mucosal Dosage Form of Insulin
- Microencapsulation and Bioavaliability in Beagle Dogs of Indomethacin
- Dissolution Kinetics for Coprecipitates of Indomethacin with Polyvinylpyrrolidone
- Ultraviolet Absorption Spectroscopy and Nuclear Magnetic Resonance Spectroscopy of Complexes of Sulfonamides with Cyclic Polyether 18-Crown-6
- Dissolution Kinetics of Complexes of Sulfamethoxazole and Sulfamonomethoxine with 18-Crown-6
- Interaction of Sulfonamides with Cyclic Polyether 18-Crown-6 in Solution and in Solid State
- Interaction of N-Methyl-2-pyrrolidone with Aminobenzoic Acids in Solution and in Solid State
- Inclusion Compounds of Non-Steroidal Antiinflammatory and Other Slightly Water Soluble Drugs with α-and β-Cyclodextrins in Powdered Form