Studies on Absorption and Excretion of Drug. VII. A New Estimation Method for the Release of Drugs from Dosage Forms and the Availability in vivo.

スポンサーリンク

概要

• 論文の詳細を見る

• The convolution equation was introduced to estimate a drug release from various dosage forms in the gut. [numerical formula] From the application of the equation, the drug release in vivo F (t) was calculated from comparison of blood level or urinary excertion of drug and/or the metablites between the ingestions of a dosage form, X (t), and the dissolved solution, G (t). The evidence of merits of this method and the deviation of the results from the real value caused by the approximation for numerical calculation were investigated by means of a theoretical model. The actual sulfamethylthiadiazole release from the tablet in human gut was estimated from the urinary excretion by using this calculation method also.

• 公益社団法人日本薬学会の論文
• 1967-07-25

著者

• 花野 学

  Faculty of Pharmaceutical Sciences, University of Tokyo

• 花野 学

  Faculty Of Pharmaceutical Sciences University Of Tokyo

関連論文

• Binding of Human Epidermal Growth Factor to Tissue Homogenates of the Rat(Pharmaceutical,Chemical)
• The Conjugative Metabolism of 4-Methylumbelliferone and Deconjugation to the Parent Drug Examined by Isolated Perfused Liver and in Vitro Liver Homogenate of Rats
• Studies on Ligand Binding Properties of Z-Fraction from Rat Liver Cytosol using 1-Anilino-8-Naphthalenesulfonate
• Pharmacokinetic Studies of Biliary Excretion. IV. The Relationship between the Biliary Excretion Behavior and the Elimination from Plasma of Azo Dyes and Triphenylmethane Dyes in Rat
• Pharmacokinetic Studies of Biliary Excretion. I. Comparison of the Excretion Behavior in Azo Dyes and Indigo Carmine
• Pharmacokinetic Aspects of Biliary Excretion. Dose Dependency of Riboflavin in Rat
• Generalized Consideration of Administration Route Dependence of Drug Disposition and Use of Urinary Data for Prediction of the Dependence
• Biliary Excretion Behavior Difference of Quaternary Ammonium Compounds between Portal Vein and Femoral Vein Infusion in Rat
• Conjugative Metabolism of 4-Methylumbelliferone in the Rat Liver : Verification of the Sequestration Process in Multiple Indicator Dilution Experiments(Pharmaceutical,Chemical)
• Effect of Urea on Intestinal Absorption of Salicylic Acid, Benzoic Acid and Aminopyrine in Rat
• Studies on Absorption and Excretion of Drugs. V. On the Mechanism of Penetration of Sulfisomezole through the Intestinal Barrier in vitro
• Studies on Absorption and Excretion of Drugs. III. Kinetics of Penetration of Sulfonamides through the Intestinal Barrier in Vitro.
• Hepatic Drug Clearance Model : Comparison among the Distributed, Parallel-Tube and Well-Stirred Models
• The Pharmacokinetic Study on the Fate of 8-Hydroxyquinoline in Rat
• A New Numerical Calculation Method for Deconvolution in Linear Compartment Analysis of Pharmacokinetics
• Kinetic Studies on Decomposition of Glutathione. III. Peptide Bond Cleavage and Desulfurization in Aqueous Solution
• Kinetic Studies on Decomposition of Glutathione. II. Anaerobic Decomposition in Aqueous Solution
• Kinetic Studies on Decomposition of Glutathione. I. Decomposition in Solid State
• Studies on Absorption and Excretion of Drugs. VI. Effects of Cations and 2,4-Dinitrophenol on the Transport of Sulfonamides through the Small Intestine of Rat
• Pharmacokinetic Aspects of Elimination from Plasma and Distribution to Brain and Liver of Barbiturates in Rat
• Thiamine Derivatives of Disulfide Type. XIV. Kinetic Studies on the Reaction between Thiamine and Propyl Propane-Thiolsulfinate or -Thiolsulfonate
• Pharmacokinetics of Thiamine Derivatives. II. Elimination of Thiamine Derivatives from the Blood of Rat
• Pharmacokinetics of Thiamine Derivatives. I. Formation of Thiamine from Thiamine Propyl Disulfide by Erythrocytes of Rat
• Solubilization of dl-α-Tocopherol by Bile Salts, Polysorbate 80 and Egg Lecithin
• In Vivo and In Vitro Fates of 8-Hydroxyquinoline Derivatives in Rat
• Various Factors affecting Intestinal Absorption of Iodochlorhydroxyquin in Rat and Man
• Differences in Species of Iodochlorhydroxyquin Absorption, Metabolism, and Excretion
• Effects of Albumin and α_1-Acid Glycoprotein on the Transport of Imipramine and Desipramine through the Blood-Brain Barrier in Rats(Pharmaceutical)
• Relationship between the Morphological Character of 5-Nitroacetyl-salicylic Acid Crystals and the Decomposition Rate in a Humid Environment
• Identification of Tissues Responsible for the Conjugative Metabolism of Liquiritigenin in Rats : An Analysis Based on Metabolite Kinetics
• Studies on Absorption and Excretion of Drug. XIII. The Sorption of Surface Active Agents into the Intestinal Tissue of Rat and Their Effect on the Drug Absorption in Vitro
• Decomposition of Acetylsalicylic Acid and Its Derivatives in Solid State
• Conformational Changes of Human Serum Albumin by Binding of Small Molecules
• Dissolution of Slightly Soluble Drugs. VI. Effect of Particle Size of Sulfadimethoxine on the Oral Bioavailability
• The Effect of Dosage Form on Absorption of Vitamin A into Lymph
• Solvent Effect of Dimethyl Sulfoxide on Alkaline Hydrolysis of Amide
• Studies on Absorption and Excretion of Drug. VII. A New Estimation Method for the Release of Drugs from Dosage Forms and the Availability in vivo.
• Studies on Percutaneous Absorption. III. Kinetics of Percutaneous Absorption.
• A Route Dependent Bioavailability in Active Metabolite Suggested in Riboflavin-5'-Phosphate Pharmacokinetics
• Pharmacokinetic Analysis on the Disappearance of Ethoxybenzamide from Plasma. Statistical Treatment of Data of Two Compartmental Model by a Digital Computer
• Studies on Absorption and Excretion of Drugs. XI. Relation between Chemical Structure and Absorption Rate. (3). Intramolecular Interaction Constant, Additivity Rule and Prediction for Intestinal Absorption Rate Coefficient
• Studies on Absorption and Excretion of Drugs. X. Relation between Chemical Structure and Absorption Rate. (2). Substituent Constant for Absorption Rate Coefficient of Foreign Organic Compounds
• Studies on Absorption and Excretion of Drugs. IX. Relation between Chemical Structure and Absorption Rate. (1). Effects of the Number and the Position of OH-Groups on the Intestinal Absorption Rate of Benzoyl Derivatives
• Studies on Absorption and Excretion of Drug. VIII. The Release Rate in vivo of Antipyretic and Analgesic Drugs from Commercial Sugar Coated Tablets.
• Studies on Absorption and Excretion of Drugs. IV. Absorption of Various Sulfonamides from the Rat Small Intestine by the Perfusion Method in vivo.
• Studies on Percutaneous Absorption. II. Effect of the Incorporated Substance.

もっと見る 閉じる

スポンサーリンク