Kinetic Studies on Decomposition of Glutathione. II. Anaerobic Decomposition in Aqueous Solution
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概要
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Kinetics studies were performed on the non-enzymatic decomposition of glutathione (GSH) in anaerobic aqueous solution. The apparent first-order rate constants of decomposition were determined in the pH range of 1-12,ionic strength 0.5,at 60° and the pH profile was constructed from the buffer-free rate constants and pH values. The decomposition of GSH took place rapidly in acidic solution, but the rate constant showed a minimum in the pH range of 5-6,a maximum at pH 8.5 and a plateau in the pH range of 10-12. The effects of ionic strength and dielectric constant were almost negligible. The apparent activation energies of decomposition of GSH were all in the range of 19-21 kcal/mol. The rate constants of decomposition were related to the mole fractions of ionic species of GSH, and could be expressed as a function of hydrogen ion activity at arbitrary pH.
- 公益社団法人日本薬学会の論文
- 1980-02-25
著者
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有賀 政義
Faculty Of Pharmaceutical Sciences University Of Tokyo:(present Address)institute Of Research And De
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花野 学
Faculty of Pharmaceutical Sciences, University of Tokyo
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粟津 荘司
Faculty of Pharmaceutical Sciences, University of Tokyo
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花野 学
Faculty Of Pharmaceutical Sciences University Of Tokyo
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