Kinetics and Mechanism of Transamination of Thiamine in the Presence of Bisulfite
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概要
- 論文の詳細を見る
The transamination reaction of thiazole moiety of thiamine (PyTh) by aromatic amine (A) in the presence of bisulfite (S) was studied kinetically. The reaction between PyTh and A was found to be second order with respect to PyTh and A, whereas the concentration of S was independent to the reaction rate. The reaction rate was linearly correlated to the pK_a value of A. The transamination product (PyA) was also degradated by S in second order as well as PyTh. The complexation between PyTh and A was also investigated as a possible proceeding process of the transamination reaction.
- 公益社団法人日本薬学会の論文
- 1975-01-25
著者
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上釜 兼人
Faculty Of Pharmaceutical Sciences Kumamoto University
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池田 憲
Faculty Of Pharmaceutical Sciences Nagoya City University
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小田切(蟹江) 陽子
Faculty Of Pharmaceutical Sciences Nagoya City University
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