Inclusion Complexes of Cyclodextrins with Cinnamic Acid Derivatives : Dissolution and Thermal Behavior
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概要
- 論文の詳細を見る
Typical B_s type phase solubility diagrams were obtained for α-and β-cyclodextrins (α-CyD and β-CyD) with methyl cinnamate, ethyl cinnamate, and cinnamaldehyde in water at 25°. Solid complexes for α-and β-CyDs with three guest molecules were obtained and their molar ratios were found to be 2 : 1 (α-CyD/guest molecule) and 1 : 1 (β-CyD/guest molecule), respectively. In sharp contrast, apparent stability constant (K_c') and dissolution rate (k_c') of α-CyD complexes were larger than those of β-CyD complexes. The thermal gravimetric analysis thermogram showed that the volatility of the guest molecule was lowered by the formation of CyD inclusion complex.
- 公益社団法人日本薬学会の論文
- 1979-01-25
著者
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平山 文俊
Faculty Of Pharmaceutical Sciences Kyushu University
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上釜 兼人
Faculty Of Pharmaceutical Sciences Kumamoto University
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井上 美智子
Faculty Of Pharmaceutical Sciences Kumamoto University
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江崎 加奈子
Faculty of Pharmaceutical Sciences, Kumamoto University
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江崎 加奈子
Faculty Of Pharmaceutical Sciences Kumamoto University
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