Partition Behavior and Ion Pair Formation of Some Prostaglandins
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概要
- 論文の詳細を見る
The pK_a and intrinsic partition coefficient (PC_0) of seven prostaglandins (PGE_1,PGE_2,PGA_1,PGA_2,PGB_1,PGB_2,and PGF_2a) were determined from their pH-partition profiles. Structural changes of the prostaglandins were largely reflected in PC_0 values rather than the pK_a values. Partition of the prostaglandins from aqueous buffer (pH7.0) to cyclohexane containing various alcohols was markedly enhanced by the addition of aliphatic amines in aqueous phase. The influences of temperature and chain length of both alcohol and amine on partition coefficients of the prostaglandins were investigated. Furthermore, extraction constants (K_e) for prostaglandin-amine ion pairs and number of alcohol molecules associated with ion pair (n) were determined to gain insight into the mechanism of enhanced extraction process.
- 公益社団法人日本薬学会の論文
- 1978-12-25
著者
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平山 文俊
Faculty Of Pharmaceutical Sciences Kyushu University
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上釜 兼人
Faculty Of Pharmaceutical Sciences Kumamoto University
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田中 晴美
Faculty Of Pharmaceutical Sciences Kumamoto University
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竹松 克美
Faculty of Pharmaceutical Sciences, Kumamoto University
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竹松 克美
Faculty Of Pharmaceutical Sciences Kumamoto University
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