ALLEVIATION OF PROCHLORPERAZINE-INDUCED PRIMARY IRRITATION OF SKIN BY CYCLODEXTRIN COMPLEXATION
スポンサーリンク
概要
- 論文の詳細を見る
Cyclodextrins (CyDs) protected human erythrocytes from hemolysis induced with prochlorperazine (PCP) in isotonic solution, depending upon the magnitude of the stability constant of PCP-CyD complexes (β- > γ- > α-CyD). The primary irritation produced by PCP on the skin of guinea pigs was found to be reduced by the addition of β- and γ-CyDs, particularly by γ-CyD, while α-CyD enhanced the irritancy of PCP. The most favorable protective effect observed for the γ-CyD complex was mainly ascribable to the weak irritancy of γ-CyD itself, suggesting a great utility of γ-CyD to alleviate the PCP-induced contact dermatitis.
- 社団法人日本薬学会の論文
- 1982-10-25
著者
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入江 徹美
熊本大・薬
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上釜 兼人
熊本大学 歯
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小田切 優樹
Faculty of Pharmaceutical Science, Kumamoto University
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上釜 兼人
Faculty Of Pharmaceutical Sciences Kumamoto University
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入江 徹美
Faculty of Pharmaceutical Sciences, Kumamoto University
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砂田 美紀
Faculty of Pharmaceutical Sciences, Kumamoto University
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有松 徳樹
Department of Public Health, Kumamoto University Medical School
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野村 茂
Department of Public Health, Kumamoto University Medical School
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有松 徳樹
?杏短期大学衛生技術科
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Irie T
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Irie Tetsumi
Dep. Of Clinical Chemistry And Informatics Graduate School Of Pharmaceutical Sciences Kumamoto Univ.
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上釜 兼人
崇城大 薬
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砂田 美紀
Faculty Of Pharmaceutical Sciences Kumamoto University
関連論文
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