IMPROVEMENT OF ORAL BIOAVAILABILITY OF PREDNISOLONE BY β-CYCLODEXTRIN COMPLEXATION IN HUMANS

概要

論文の詳細を見る
Inclusion complex of prednisolone with β-cyclodextrin (β-CyD) in 1 : 2 molar ratio was prepared and its dissolution, membrane permeation and oral absorption behaviors were examined. The rates of dissolution and permeation through a cellophane membrane in water were significantly increased by β-CyD complexation. A crossover bioavailability study was performed using human subjects with lower doses of prednisolone tablets, where the plasma levels of the drug were determined by radioimmunoassay. The enhanced bioavailability of prednisolone by β-CyD complexation suggested the possibility of smaller doses and fewer side effects in prednisolone therapy.
公益社団法人日本薬学会の論文