REDUCTION IN THE LOCAL TISSUE TOXICITY OF CHLORPROMAZINE BY β-CYCLODEXTRIN COMPLEXATION
スポンサーリンク
概要
- 論文の詳細を見る
Effect of β-cyclodextrin (β-CyD) on the local tissue toxicity of chlorpromazine (CPZ) was investigated following the intramuscular injection to rabbits. From the gross and histological examinations, β-CyD was found to alleviate the muscular tissue damage produced by CPZ on M. vastus lateralis in rabbits. The protective effect of β-CyD may be ascribed to the decrease in affinity of CPZ to the tissue membrane through inclusion complexation. The present data suggest that β-CyD complexation is particularly useful to reduce the local toxicity of phenothiazine neuroleptics without altering the pharmacological efficacy.
- 公益社団法人日本薬学会の論文
著者
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UEKAMA Kaneto
Faculty of Pharmaceutical Sciences, Sojo University
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IRIE Tetsumi
Faculty of Pharmaceutical Sciences, Kumamoto University
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上釜 兼人
熊本大学 歯
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IWAMASA Teruo
Department of Pathology, Ryukyu University School of Medicine
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Irie Tetsumi
Faculty Of Pharmaceutical Sciences Kumamoto University
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Iwamasa Teruo
Division of Pathology and Cell Biology, University of the Ryukyus
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OTAGIRI MASAKI
Faculty of Pharmaceutical Science, Kumamoto University
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Iwamasa T
Department Of Pathology Ryukyu University School Of Medicine
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Iwamasa Teruo
Department Of Pathology Kumamoto University Hospital
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Iwamasa Teruo
Department Of Clinical Chemistry And Pathology Shimonoseki Chuo General Hospital
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Otagiri M
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Uekama Kaneto
Faculty Of Pharmaceutical Sciences Kumamoto University
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KUWAHARA SHINJI
Faculty of Pharmaceutical Sciences, Kumamoto University
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Kuwahara Shinji
Faculty Of Pharmaceutical Sciences Kumamoto University
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Otagiri Masaki
Faculty Of Pharmaceutical Science Kumamoto University
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