CYCLODEXTRIN-INDUCED HEMOLYSIS AND SHAPE CHANGES OF HUMAN ERYTHROCYTES IN VITRO
スポンサーリンク
概要
- 論文の詳細を見る
Cyclodextrins (CyDs) at higher concentrations were found to cause hemolysis of human erythrocytes in the order of β->α->γ-CyD in isotonic solution. Biphasic effects of CyDs were observed for the osmotic and heat-induced hemolysis; i.e. the protection at relatively low CyD concentrations and stimulation at higher CyD concentrations. From the scanning electron microscopic observations, CyDs induced shape changes of membrane internalization type on erythrocytes. CyDs caused the release of cholesterol from erychrocyte membrane in the order of β->γ->α-CyD. These results dearly indicate that CyD-induced hemolysis is probably a secondary event resulting from the membrane disruption which elicited the removal of membrane components from erythrocytes.
- 公益社団法人日本薬学会の論文
著者
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IRIE Tetsumi
Faculty of Pharmaceutical Sciences, Kumamoto University
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Irie Tetsumi
Faculty Of Pharmaceutical Sciences Kumamoto University
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OTAGIRI MASAKI
Faculty of Pharmaceutical Science, Kumamoto University
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Yamada Yoshitsugu
Kaken Chemical Co. Ltd.
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Otagiri M
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Sugiyama Yukio
Kaken Chemical Co. Ltd.
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Uekama Kaneto
Faculty Of Pharmaceutical Sciences Kumamoto University
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Ohtani Yoshiro
Kaken Chemical Co. Ltd.
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SUNADA MIKI
Faculty of Pharmaceutical Sciences, Kumamoto University
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Otagiri Masaki
Faculty Of Pharmaceutical Science Kumamoto University
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Sunada Miki
Faculty Of Pharmaceutical Sciences Kumamoto University
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