EFFECT OF PHENYLBUTAZONE ON SERUM PROTEIN BINDING OF SULFADIMETHOXINE IN DIFFERENT ANIMAL SPECIES
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概要
- 論文の詳細を見る
The effect of phenylbutazone (PBZ) on the in vivo serum protein binding of sulfadimethoxine (SDM) was examined in dogs, rabbits and rats. In dogs, PBZ itself was found to displace SDM from its protein binding sites. In rabbits, PBZ indirectly reduced the in vivo serum protein binding of SDM through the interaction of PBZ with N^4-acetylsulfadimethoxine (N^4-AcSDM), a major metabolite of SDM. In rats, however, PBZ had no effect on the in vivo serum protein binding of SDM. It is noteworthy that species differences were observed in the effect of PBZ on the in vivo serum protein binding of SDM.
- 公益社団法人日本薬学会の論文
著者
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Nakamura H
Kobe Univ. School Of Medicine Kobe Jpn
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Imamura Y
Kumamoto Univ. Kumamoto Jpn
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Imamura Yorishige
Faculty Of Pharmaceutical Sciences Kumamoto University
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OTAGIRI MASAKI
Faculty of Pharmaceutical Science, Kumamoto University
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Otagiri M
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Otagiri M
Kumamoto Univ. Kumamoto Jpn
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NAKAMURA Hideki
Faculty of Pharmaceutical Sciences, Kumamoto University
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Otagiri Masaki
Faculty Of Pharmaceutical Science Kumamoto University
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