PROTECTIVE MECHANISM OF β-CYCLODEXIRIN FOR THE HEMOLYSIS INDUCED WITH PHENOTHIAZINE NEUROLEPTICS IN VITRO
スポンサーリンク
概要
- 論文の詳細を見る
β-Cyclodextrin (β-CyD) was found to protect the human erythrocytes from the hemolysis induced with ten phenothiazine neuroleptics in isotonic solution. The hemolytic activities of the phenothiazine-β-CyD systems appeared to depend upon the free phenothiazine concentration, suggesting that the complexed form of phenothiazines is essentially inactive to cause hemolysis. The binding abilities and surface activities of the complexed form of phenothiazines were much smaller than those of free phenothiazines. These results indicate that the protective effect of β-CyD may be due to the decrease in the effective hemolytic concentration of phenothiazines by inclusion complexation rather than the stabilizing effect of β-CyD on the erythrocyte membrane.
- 公益社団法人日本薬学会の論文
著者
-
IRIE Tetsumi
Faculty of Pharmaceutical Sciences, Kumamoto University
-
上釜 兼人
熊本大学 歯
-
Irie Tetsumi
Faculty Of Pharmaceutical Sciences Kumamoto University
-
OTAGIRI MASAKI
Faculty of Pharmaceutical Science, Kumamoto University
-
Otagiri M
Graduate School Of Pharmaceutical Sciences Kumamoto University
-
Uekama Kaneto
Faculty Of Pharmaceutical Sciences Kumamoto University
-
SUNADA MIKI
Faculty of Pharmaceutical Sciences, Kumamoto University
-
Otagiri Masaki
Faculty Of Pharmaceutical Science Kumamoto University
-
Sunada Miki
Faculty Of Pharmaceutical Sciences Kumamoto University
関連論文
- Involvement of Lipid Rafts of Rabbit Red Blood Cells in Morphological Changes Induced by Methylated β-Cyclodextrins(Biopharmacy)
- Pseudorotaxane-Like Supramolecular Complex of Coenzyme Q10 with γ-Cyclodextrin Formed by Solubility Method
- Improved Stability of OPALMON^[○!R] Tablets under Humid Conditions IV : Effect of Polysaccharides and Disintegrants on the Stability and Dissolution Property of OPALMON^[○!R] Tablets
- Improvement of Dissolution Properties of a New Helicobacter pylori Eradicating Agent (TG44) by Inclusion Complexation with β-Cyclodextrin
- Improvement of Solubility and Oral Bioavailability of 2-(N-Cyanoimino)-5-{(E)-4-styrylbenzylidene}-4-oxothiazolidine (FPFS-410) with Antidiabetic and Lipid-Lowering Activities in Dogs by 2-Hydroxypropyl-β-cyclodextrin
- Preparation and Pharmaceutical Evaluation of Liposomes Entrapping Salicylic Acid/γ-Cyclodextrin Conjugate
- Enhancing Effects of Galactosylated Dendrimer/α-Cyclodextrin Conjugates on Gene Transfer Efficiency(Biopharmacy)
- Effects of Cyclodextrins on the Aggregation of Recombinant Human Growth Hormone (rhGH)
- A Moderate Interaction of Maltosyl-α-cyclodextrin with Caco-2 Cells in Comparison with the Parent Cyclodextrin
- Analysis of the Phase Solubility Diagram of a Phenacetin/Competitor/β-Cyclodextrin Ternary System, Involving Competitive Inclusion Complexation
- Hydrolysis Behavior of Prednisolone 21-Hemisuccinate/β-Cyclodextrin Amide Conjugate : Involvement of Intramolecular Catalysis of Amide Group in Drug Release
- Effects of Aging on Crystallization, Dissolution and Absorption Characteristics of Amorphous Tolbutamide-2-Hydroxypropyl-β-cyclodextrin Complex
- Inhibitory Effect of 2-Hydroxypropyl-β-cyclodextrin on the Foaming Generated by the Phosphodiester Compound of Vitamin C and E, EPC-K1
- Enhanced Absorption of Cyclosporin A be Complexation with Dimethyl-β-cyclodextrin in Bile Duct-Cannulated and -Noncannulated Rats
- シクロデキストリン polypseudorotaxane によるPEG化タンパク質持続放出システムの構築
- 抗ヒスタミン薬とシクロデキストリンの相互作用ならびに苦味軽減効果
- ジメチルアセチル-β-シクロデキストリンによるエンドトキシンショック抑制作用
- 薬物/シクロデキストリン結合体封入リポソームによる薬物の体内動態の制御
- 糖修飾デンドリマー/シクロデキストリン結合体を用いた細胞特異的遺伝子デリバリー
- ジメチル-β-シクロデキストリンによる薬物排出ポンプの機能阻害におけるCaveolaeの関与
- シクロデキストリン結合体を利用したケトプロフェンの経口持続性製剤の設計
- ジメチル-β-シクロデキストリンによるP-糖タンパク質の機能阻害におけるCaveolaeの関与
- 薬物/シクロデキストリン複合体封入リポソームの薬物送達システムへの応用
- シクロデキストリン誘導体によるマクロファージからのNO産生の抑制効果
- 遅延放出製剤の設計における薬物/シクロデキストリン結合体の有効利用
- 抗炎症薬ビフェニル酢酸の直腸投与における薬物担体としての水溶性β-シクロテキストリン誘導体の有効利用
- ビフェニル酢酸の坐剤への応用におけるβ-シクロデキストリン複合体の有用性について
- エチルセルロース固体分散体からのメトプロロール放出に及ぼす2-ヒドロキシプロピル-β-シクロデキストリンの影響
- O-Carboxymethyl-O-ethyl-β-cyclodextrinによる1-Hexylcarbamoyl-5-fluorouracil (HCFU) の安定性及びバイオアベイラビリティの向上
- ジメチル-β-シクロデキストリン複合体化によるメナキノン-4 の経口投与時のバイオアベイラビリティの改善
- 遺伝子組換えヒト成長ホルモンの凝集反応に及ぼす親水性シクロデキストリンの影響
- Varying Effects of Cyclodextrin Derivatives on Aggregation and Thermal Behavior of Insulin in Aqueous Solution
- Spectroscopic Characterization of the Inclusion Complex of a Luteinizing Hormone-Releasing Hormone Agonist, Buserelin Acetate, with Dimethyl-β-cyclodextriin
- 脂肪酸/シクロデキストリン併用系によるプロスタサイクリン誘導体ベラプロストの経皮吸収の制御
- 塩酸モルヒネの経鼻吸収および脳内移行に及ぼすシクロデキストリン誘導体の影響
- Enhanced Nasal Delivery of Luteinizing Hormone Releasing Hormone Agonist Buserelin by Oleic Acid Solubilized and Stabilized in Hydroxypropyl-β-cyclodextrin
- Characterization of the Inclusion Mode of β-Cyclodextrin Sulfate and Its Effect on the Chlorpromazine-Induced Hemolysis of Rabbit Erighrocytes
- Stabilization of Prostaglandin E_1 in Fatty Alcohol Propylene Glycol Ointment by Acidic Cyclodextrin Derivative, O-Carboxymethyl-O-ethyl-β-cyclodextrin
- Utility of 2-Hydroxypropyl-β-cyclodextrin in an Intramuscular Injectable Preparation of Nimodipine
- Some Pharmaceutical Properties of 3-Hydroxypropyl- and 2,3-Dihydroxypropyl-β-cyclodextrins and Their Solubilizing and Stabilizing Abilities
- β-及びジメチルβ-シクロデキストリン包接によるクロミプラミンの光化学反応性変化
- Improvement in Percutaneous Absorption of Prednisolone by β- and γ-Cyclodextrin Complexations(Pharmaceutical)
- プレドニゾロンの各種軟膏基剤からの放出及び経皮吸収に対するβ-及びジメチルβ-シクロデキストリンの影響
- Analysis of Interfacial Transfer and Absorption Behavior of Drugs Following Dissolution from β-Cyclodextrin Complexes
- ALLEVIATION OF PROCHLORPERAZINE-INDUCED PRIMARY IRRITATION OF SKIN BY CYCLODEXTRIN COMPLEXATION
- シクロデキストリン包接によるチアムリン注射時の局所刺激性の改善
- トリバレリル化β-シクロデキストリン膜を用いた水溶性薬物の放出制御
- 各種シクロデキストリンによるシクロスポリンAの消化管吸収およびリンパ移行の改善
- ニルバジピン一水和物の結晶構造と多形転移挙動
- 高機能性シクロデキストリンの医薬への応用(魅惑の超分子ワールド)
- Inclusion Mode of Flurbiprofen with β-Cyclodextrin and Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin, and Improvements of Some Pharmaceutical Properties of Flurbiprofen by Complexation
- Preparation of Hydrophilic Nanoparticles of C_ with High Resistance to Aggregation during Storage, using 2-Hydroxypropyl-β-cyclodextrin
- Prominent Inhibitory Effect of 2-Hydroxybutyl-β-cyclodextrin on Solution-mediated Polymorphic Transition of Chlorpropamide
- Effects of Cyclodextrins on Degradations of Emetine and Cephaeline in Aqueous Solution
- Interaction of the Fluorescent Probe 7-Anilino-4-methylcoumarin-3-acetic Acid with α-Globulin
- Interaction between Methacycline and Human Serum Albumin
- X-RAY CRYSTALLOGRAPHIC DETERMINATION OF THE ABSOLUTE CONFIGURATION OF (+) FLURBIPROFEN UTILIZING β-CYCLODEXTRIN COMPLEXATION
- CRYSTAL AND MOLECULAR STRUCTURE OF 2 : 2 (±) FLURBIPROFEN-β-CYCLODEXTRIN COMPLEX
- 水溶液中におけるインドメタシンおよびその関連化合物とシクロデキストリンとの包接複合体形成
- Transparent, Adhesive Film Formation of Per-O-valeryl-β-cyclodextrin
- INCLUSION COMPLEXATIONS OF FLURBIPROFEN WITH β-CYCLODEXTRIN AND TRI-O-METHYL-β-CYCLODEXTRIN
- Inclusion Complexation of p-Hydroxybenzoic Acid Esters with 2-Hydroxypropyl-β-cyclodextrins. On Changes in Solubility and Antimicrobial Activity
- Enhancement of Oral Bioavailability of Spironolactone by β- and γ-Cyclodextrin Complexations
- Improvement of Dissolution Characteristics and Chemical Stability of Prostaglandin E_1 by γ-Cyclodextrin Complexation
- β-シクロデキストリン包接による消炎鎮痛薬ピルプロフェンの安定化と刺激味の軽減
- Electrochemical Oxidation of Chlorpromazine-Cyclodextrin Inclusion Complex
- Electrochemical Oxidation of Chlorpromazine Hydrochloride in Aqueous Buffer
- Improvement of Stability and Dissolution of Prostaglandin E_1 by Maltosyl-β-cyclodextrin in Lyophilized Formulation
- Improvement of Chemical Instability of Digitoxin in Aqueous Solution by Complexation with β-Cyclodextrin Derivatives
- Improvement of Dissolution Characteristics of a New Chalcone Derivative, SU-740 : Comparison between Size Reduction, Solid Dispersion and Inclusion Complexation
- Possible Enhancing Mechanism of the Cutaneous Permeation of 4-Biphenylylacetic Acid by β-Cyclodextrin Derivatives in Hydrophilic Ointment
- COMBINED USE OF CYCLODEXTRIN DERIVATIVES AND PENETRATION ENHANCER HPE-101 IN TRANSDERMAL DELIVERY OF PROSTAGLANDIN E_1
- γ-シクロデキストリン複合体化によるジゴキシンのバイオアベイラビリティの向上 : ヒトにおける舌下及び経口投与時の評価
- 2-Hydroxypropylated Cyclodextrins as a Sustained-Release Carrier for Fragrance Materials
- β-シクロデキストリン包接による7位置換クマリン誘導体の螢光挙動
- Effects of α_1-Acid Glycoprotein on Erythrocyte Deformability and Membrane Stabilization(Biopharmacy)
- Inclusion Complex of 3,9-Bis(N, N-dimethylcarbamoyloxy)-5H-benzofuro[3,2-c]quinoline-6-one (KCA-098) with Heptakis(2,6-di-O-methyl)-β-cyclodextrin : Interaction and Dissolution Properties
- シクロデキストリンとの複合体形成によるアラルキルアルコール類の製剤特性の向上
- サイクロデキストリンの医薬への応用 (アミラ-ゼシンポジウム(1982)特集〔含 討論〕)
- 7-位置換クマリン誘導体のアルカリ加水分解反応におよぼすシクロデキストリンの影響 (「包接現象の化学」)
- 機能性製剤素材シクロデキストリン
- 1-Hexylcarbamoyl-5-fluorouracil(HCFU)の経口及び直腸吸収に及ぼすジメチルβ-シクロデキストリンの影響
- Effect of Simultaneous Administration of Drugs on Absorption and Excretion. XVIII. Differential Effects of Oral and Rectal Administration of Chloral Hydrate on the Gastrointestinal Absorption of Sulfisoxazole in Rabbits
- Effects of β- and γ-Cyclodextrins on Release of Betamethasone from Ointment Bases
- γ-シクロデキストリンとの包接複合体形成によるチオペンタールの製剤特性の向上
- ALLEVIATION OF CHLORPROMAZINE-PHOTOSENSITIZED CONTACT DERMATITIS BY β-CYCLODEXTRIN DERIVATIVES AND THEIR POSSIBLE MECHANISMS
- REDUCTION IN PHOTOTOXICITY OF DRUGS BY CYCLODEXTRIN COMPLEXATIONS AND ITS POSSIBLE MECHANISM
- MODEL ANALYSIS OF INTERFACIAL TRANSFER AND ABSORPTION BEHAVIOR OF DRUG FOLLOWING DISSOLUTION FROM COMPRESSED TABLET : IN THE CASES OF SULFONAMIDES AND β-CYCLODEXTRIN COMPLEXES
- IMPROVEMENT OF ORAL BIOAVAILABILITY OF PREDNISOLONE BY β-CYCLODEXTRIN COMPLEXATION IN HUMANS
- ENHANCED ORAL BIOAVAILABILITY OF ANTIINFRAMMATORY DRUG FLURBIPROFEN IN RABBITS BY TRI-O-METHYL-β-CYCLODEXTRIN COMPLEXATION
- Pharmaceutical Evaluation of Hydroxyalkylated β-Cyclodextrin Derivatives
- REDUCTION IN THE LOCAL TISSUE TOXICITY OF CHLORPROMAZINE BY β-CYCLODEXTRIN COMPLEXATION
- Improvement of Chemical Instability of Carmoful in β-Cyclodextrin Solid Complex by Utilizing Some Organic Acids(Pharmaceutical)
- 親水性ならびに疎水性β-シクロデキストリン誘導体によるプロスタグランジンE1の放出制御 (高機能両親媒性化合物の合成とその高次構造) -- (両親媒性化合物)
- Mechanisms of Deceleration by Methylated Cyclodextrins in the Dehydration of Prostaglandin E_2 and the Isomerization of Prostaglandin A_2 in Aqueous Solution(Pharmaceutical)
- REDUCTION IN THE LOCAL TOXICITY OF CHLORPROMACINE AND ITS PHOTOPRODUCTS BY CYCLODEXTRIN COMPLEXATION
- PROTECTIVE MECHANISM OF β-CYCLODEXIRIN FOR THE HEMOLYSIS INDUCED WITH PHENOTHIAZINE NEUROLEPTICS IN VITRO
- CYCLODEXTRIN-INDUCED HEMOLYSIS AND SHAPE CHANGES OF HUMAN ERYTHROCYTES IN VITRO
- PROTECTIVE EFFECTS OF CYCLODEXTRINS ON THE HEMOLYSIS INDUCED WITH TRANQUILIZING PHENOTHIAZINES
- PROTECTIVE EFFECTS OF CYCLODEXTRINS ON DRUG-INDUCED HEMOLYSIS IN VITRO