PROTECTIVE EFFECTS OF CYCLODEXTRINS ON DRUG-INDUCED HEMOLYSIS IN VITRO
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概要
- 論文の詳細を見る
β-Cyclodextrin (β-CyD) significantly protected the human erythrocytes from hemolysis and shape changes induced with chlorpromazine and flufenamic acid in isotonic solution. A good correlation between the stability constants of inclusion complexes (β->γ->α-CyD) and the inhibitory effects on drug-induced hemolysis was found. From the observations of drug uptake into erythrocytes and changes in surface tension, the protective effects of CyDs appeared to be due to the decrease in effective concentration of drug through inclusion complexation rather than the direct interaction of CyDs with erythrocyte membrane.
- 公益社団法人日本薬学会の論文
著者
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IRIE Tetsumi
Faculty of Pharmaceutical Sciences, Kumamoto University
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Irie Tetsumi
Faculty Of Pharmaceutical Sciences Kumamoto University
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OTAGIRI MASAKI
Faculty of Pharmaceutical Science, Kumamoto University
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Uekama Kaneto
Faculty Of Pharmaceutical Sciences Kumamoto University
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SUNADA MIKI
Faculty of Pharmaceutical Sciences, Kumamoto University
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TSUBAKI KENICHI
Department of Pharmacy, Kumamoto University Hospital
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Otagiri Masaki
Faculty Of Pharmaceutical Science Kumamoto University
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Sunada Miki
Faculty Of Pharmaceutical Sciences Kumamoto University
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Tsubaki Kenichi
Department Of Pharmacy Kumamoto University Hospital
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