ENHANCED BIOAVAILABILITY OF DIGOXIN BY γ-CYCLODEXTRIN COMPLEXATION
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概要
- 論文の詳細を見る
Inclusion complex of digoxin with γ-cyclodextrin (γ-CyD) in 1 : 4 molar ratio was prepared, and its dissolution and absorption behaviors were compared with those of digoxin alone. The dissolution rate of digoxin in water was found to be markedly in creased by γ-CyD complexation. Bioavailability of digoxin following the oral administration of γ-CyD complex to dogs was 5.4 times as much as that of digoxin alone. The present data did indicate the improvement of dissolution and absorption characteristics of digoxin by inclusion complexation, suggesting the decrease in dose in oral digoxin therapy.
- 公益社団法人日本薬学会の論文
著者
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OTAGIRI MASAKI
Faculty of Pharmaceutical Science, Kumamoto University
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Otagiri M
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Otagiri M
Kumamoto Univ. Kumamoto Jpn
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Uekama Kaneto
Faculty Of Pharmaceutical Sciences Kumamoto University
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FUJINAGA TOSHIO
Faculty of Pharmaceutical Sciences, Kumamoto University
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Fujinaga Toshio
Faculty Of Pharmaceutical Sciences Kumamoto University
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Tsuruoka Michio
Department Of Pharmacy Miyazaki Medical College Hospital
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Tsuruoka Michio
Department Of Pharmacy Miyazaki Medical College
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SEO HAKARU
Department of Pharmacy, Miyazaki Medical College Hospital
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Seo Hakaru
Department Of Pharmacy Miyazaki Medical College Hospital
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Otagiri Masaki
Faculty Of Pharmaceutical Science Kumamoto University
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