Sex-Dependent Pharmacokinetics and in Vitro Reductive Metabolism of Acetohexamide in Wistar-Imamichi Rats
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概要
- 論文の詳細を見る
A significant sex-related difference was observed for the pharmacokinetics of acetohexamide in Wister-Imamichi (Wistar-IM) rats. However, there was no sex difference of the in vitro reductive metabolism of acetohexamide in the liver or kidney of these rats. Testectomy was found to decrease the plasma clearance (CL_p) of acetohexamide in male rats, whereas ovariectomy had no effect on the CL_p of acetohexamide in female animals, suggesting that androgens regulate the pharmacokinetics of acetohexamide. The co-administration of sulfamethazine, which is known to be metabolized by a male-specific cytochrome P450 (CYP) isoform (CYP2C11), significantly decresed the CL_p of acetohexamide in male Wister-IM rats. Based on these results, it is reasonable to assume that the sex-dependent pharmacokinetics of acetohexamide observed in Wister-IM rats is associated with the male-specific hydroxylation catalyzed by CYP2C11.
- 公益社団法人日本薬学会の論文
- 1999-04-15
著者
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Mori Y
Faculty Of Pharmaceutical Sciences Kumamoto University
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Mori Yukiko
熊本大学 薬
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Kaneko Miho
Faculty Of Pharmaceutical Sciences Kumamoto University
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Imamura Y
Kumamoto Univ. Kumamoto Jpn
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Imamura Yorishige
Faculty Of Pharmaceutical Sciences Kumamoto University
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OTAGIRI MASAKI
Faculty of Pharmaceutical Science, Kumamoto University
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MORI Yukiko
Faculty of Pharmaceutical Sciences, Kumamoto University
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Otagiri M
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Otagiri M
Kumamoto Univ. Kumamoto Jpn
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Otagiri Masaki
Faculty Of Pharmaceutical Science Kumamoto University
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Mori Y
Dep. Of Biotechnology Fac. Of Engineering Toyama Prefectural Univ.
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