Inhibition of Rabbit Heart Carbonyl Reductase by Fatty Acids
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概要
- 論文の詳細を見る
The inhibition of rabbit heart carbonyl reductase (PHCR) by fatty acids was examined using 4-benzoylpyridine (4BP) as a substrate. The inhibitory potency of saturated fatty acids increased with elongation in the carbon chain from caprylic acid to myristic acid, but decreased with further elongation. Myristic acid with 14 carbon atoms most strongly inhibited RHCR. All of the unsaturated fatty acids tested strongly inhibited RHCR; the cisisomers were more potent inhibitors than the corresponding trans-isomers. The methyl esters and alcohols, which lack a carboxyl group, derived from fatty acids did not exert a significant inhibitory effect on RHCR. These results indicate that the existence of a proper length of carbon chain, double bond(s), and a carboxyl group in a fatty acid molecule is important for RHCR inhibition. We also propose the possibility that myristic acid at low concentrations inhibits the reduction of 4BP by interacting with a binding site other than the coenzyme- and substrate-binding sites of RHCR.
- 公益社団法人日本薬学会の論文
- 1999-07-15
著者
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Imamura Yorishige
Faculty Of Pharmaceutical Sciences Kumamoto University
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OTAGIRI MASAKI
Faculty of Pharmaceutical Science, Kumamoto University
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ANRAKU Makoto
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University
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Anraku Makoto
Fac. Of Pharmacy And Pharmaceutical Sciences Fukuyama Univ.
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Anraku Makoto
Faculty Of Pharmaceutical Sciences Kumamoto University
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MIGITA Toyohiko
Faculty of Pharmaceutical Sciences, Kumamoto University
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Migita Toyohiko
Faculty Of Pharmaceutical Sciences Kumamoto University
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Otagiri Masaki
Faculty Of Pharmaceutical Science Kumamoto University
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