High Levels of Oxidative Stress Exist in the Brain than Serum or Kidneys in Stroke-Prone Spontaneously Hypertensive Rats at Ten Weeks of Age

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概要

• 論文の詳細を見る

• In the present study, we examined levels of oxidative stress in the serum, brain and kidneys of normotensive Wistar Kyoto rats (WKY) and stroke prone spontaneously hypertensive rats (SHRSP) at 10 weeks of age. Levels of advanced oxidation protein products (AOPP), oxidized albumin and oxidized proteins, markers of oxidative stress, were significantly decreased in serum among SHRSP as compared with WKY. Levels of oxidized proteins determined by immunoblotting were significantly increased in the brain, but not kidney, of SHRSP. The mRNA level of super oxide dismutase (SOD) determined by real time polymerase chain reaction (PCR) and the protein level of catalase assessed by immunoblotting were significantly increased in the brain of SHRSP. From these results, it was suggested that levels of oxidative stress were higher in the brain than serum or kidneys of SHRSP at 10 weeks of age, but are not caused by decreases in the expression of SOD and catalase.

• 日本薬学会の論文

著者

• MICHIHARA Akihiro

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• AKASAKI Kenji

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Miura Ayako

  京都府立医科大学 法医学

• Akasaki Kenji

  Faculty Of Pharmacy & Pharmaceutical Sciences Of Fukuyama University

• Anraku Makoto

  Fac. Of Pharmacy And Pharmaceutical Sciences Fukuyama Univ.

• Anraku Makoto

  Faculty Of Pharmaceutical Sciences Kumamoto University

• Shimatani Mai

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Tomida Hisao

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

• Anraku Makoto

  Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University

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