Effects of Repeated Clarithromycin Administration on the Pharmacokinetic Properties of Pindolol in Rats
スポンサーリンク
概要
- 論文の詳細を見る
The goal of the present work was to determine the effect of clarithromycin (CAM) administration on the pharmacokinetic properties of pindolol in rats. The binding of pindolol to serum components increases proportionally with increasing α_1-acid glycoprotein (AGP) concentration, indicating that AGP might play a major role in the binding of pindolol. After intravenous administration of pindolol to rats, the CAM-treated group showed a decrease in the volume of distribution, an increase in AUC and no change in the half-life as compared to the control group. Treatment with CAM increased the AGP concentration only. The serum concentration of albumin and creatinine, as well as the metabolic activity of hepatic microsomes towards pindolol, were not altered. Good correlation was observed between the AUC of pindolol in rats and the AGP concentration in serum. Moreover, at 5 min after the administration of an intravenous bolus dose of pindolol to CAM-treated rats, the free concentration of pindolol was lower but the total concentration was higher, compared with the control rats. These results suggested that the influence of CAM on the pharmacokinetic properties of pindolol in CAM-treated rats can be explained by protein binding which, in turn, may be associated with variations in AGP concentration.
- 公益社団法人日本薬学会の論文
- 1998-12-15
著者
-
Harashima Hideyoshi
Faculty of Pharmaceutical Sciences, Hokkaido University
-
OTAGIRI MASAKI
Faculty of Pharmaceutical Science, Kumamoto University
-
Harashima Hideyoshi
Faculty Of Pharmaceutical Science The University Of Tokushima
-
Harashima Hideyoshi
Faculty Of Pharmaceutical Sciences Tokushima University
-
KOMORI Takafumi
Faculty of Pharmaceutical Sciences, Kumamoto University
-
SHIMOISHI Kazuki
Faculty of Pharmaceutical Sciences, Kumamoto University
-
Shimoishi Kazuki
Graduate School Of Pharmaceutical Sciences Kumamoto Univ.
-
Otagiri Masaki
Faculty Of Pharmaceutical Science Kumamoto University
-
Komori Takafumi
Faculty Of Pharmaceutical Sciences Kumamoto University
関連論文
- Correlation between the Phosphohydrolase Activity of the Escherichia coli Orf135 (NudG) Protein and Mutation Suppression
- Ornithine and Tryptophan Analogs as Efficient Polycations for Short Interference RNA Delivery to Tumor Cells
- Enzymatic Hydrolysis of the Horn and Hoof of Cow and Buffalo
- Recognition of Nucleotide Analogs Containing the 7,8-Dihydro-8-oxo Structure by the Human MTH1 Protein
- Kinetic Analysis of the Positive Inotropic Action (PIA) of Ouabain in Isolated Perfused Rabbit Heart. Slow Onset of PIA and Slow Binding to Na^+, K^+-Adenosine Triphosphatase
- PREDICTION OF SERUM CONCENTRATION TIME COURSE OF QUINIDINE IN HUMAN USING A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL DEVELOPED FROM THE RAT
- PREDICTION OF THE PLASMA CONCENTRATION TIME COURSES OF VARIOUS DRUGS IN HUMANS BASED ON DATA FROM RATS
- INCLUSION COMPLEXATIONS OF FLURBIPROFEN WITH β-CYCLODEXTRIN AND TRI-O-METHYL-β-CYCLODEXTRIN
- Interaction Mode of Dicumarol and Its Derivatives with Human Serum Albumin, α_1-Acid Glycoprotein and Asialo α_1-Acid Glycoprotein
- Induction of Substitution and Deletion Mutations by 2-Hydroxyadenine during Replication in a HeLa Extract
- Catalytic Properties for Naphthoquinones and Partial Primary Structure of Rabbit Heart Acetohexamide Reductase
- Carbonyl Reductase Purified from Rabbit Liver Is Not the Product of a Carbonyl Reductase Gene (RCBR5 or RCBR6) Cloned from the Rabbit Liver cDNA Library
- Characterization of Acetohexamide Reductases Purified from Rabbit Liver, Kidney, and Heart: Structural Requirements for Substrates and Inhibitors
- Purifiation and Catalytic Properties of a Novel Acetohexamide-Reducing Enzyme from Rabbit Heart
- Stereoselective Reduction of Acetohexamide in Cytosol of Rabbit Liver
- Cytotoxic Effect of Drosophila Deoxynucleoside Kinase Gene on Replicating Plasmid in HeLa Cells
- Induction of Various Mutations during PCRs with Manganese and 8-Hydroxy-dGTP
- Effects of Target Sequence and Sense versus Anti-sense Strands on Gene Correction with Single-stranded DNA Fragments
- In Vivo Studies on the Role of Complement in the Clearance of Liposomes in Rats and Guinea Pigs
- Effects of non-B DNA sequences on transgene expression
- Stability of a Cisplatin-Chondroitin Sulfate A Complex in Plasma and Kidney in Terms of Protein Binding
- Effect of Polyethyleneglycol Spacer on the Binding Properties of Nuclear Localization Signal-Modified Liposomes to Isolated Nucleus
- Sex-Dependent Pharmacokinetics and in Vitro Reductive Metabolism of Acetohexamide in Wistar-Imamichi Rats
- Individual Variation of Acetohexamide Reductase Activities in Liver Microsomes and Cytosol of Rats
- High-performance liquid chromatography with chemiluminescence detection of penbutolol and its hydroxylated metabolite in rat plasma
- Kinetic Analysis of the Interaction between Liposomes and the Complement System in Rat Serum : Re-evaluation of Size-Dependency
- Complement Dependent and Independent Liposome Uptake by Peritoneal Macrophages : Cholesterol Content Dependency
- Effects of Repeated Clarithromycin Administration on the Pharmacokinetic Properties of Pindolol in Rats
- KINETIC ANALYSIS OF THE UPTAKE PROCESS OF LIPOSOMES BY RES
- Effects of α_1-Acid Glycoprotein on Erythrocyte Deformability and Membrane Stabilization(Biopharmacy)
- Characterization of Ligand Binding Sites on the α_1-Acid Glycoprotein in Humans, Bovines and Dogs
- EFFECT OF REPEATED ADMINISTRATION OF PYRIDINOLCARBAMATE ON THE RENAL EXCRETION OF SOME DRUGS IN RABBITS
- Characterization of a Binding Site of UCN-01,a Novel Anticancer Drug on α_1-Acid Glycoprotein
- Inclusion Complex of 3,9-Bis(N, N-dimethylcarbamoyloxy)-5H-benzofuro[3,2-c]quinoline-6-one (KCA-098) with Heptakis(2,6-di-O-methyl)-β-cyclodextrin : Interaction and Dissolution Properties
- Effect of Grinding with Hydroxypropyl Cellulose on the Dissolution and Particle Size of a Poorly Water-Soluble Drug
- Inhibitory Effects of Flavonoids on Rabbit Heart Carbonyl Reductase
- Inhibition of Rabbit Heart Carbonyl Reductase by Fatty Acids
- Purification and Catalytic Properties of a Tetrameric Carbony1 Reductase from Rabbit heart
- STUDIES ON BEFUNOLOL REDUCTASE FROM RABBIT LIVER
- In Vivo and in Vitro Binding of (-)-Hydroxyhexamide, a Major Metabolite of Acetohexamide, to Rabbit Serum
- Metabolic Reduction of Acetohexamide in Rat Kidney : Sex Difference and Effect of Streptozotocin-Induced Diabetes
- SEX DIFFERENCE OF ACETOHEXAMIDE REDUCTION IN RAT LIVER
- EFFECTS OF VARIOUS FACTORS ON METABOLIC REDUCTION OF ACETOHEXAMIDE
- REDUCTION OF ACETOHEXAMIDE BY RABBIT HEART CYTOSOL
- Effect of Phenylbutazone on Serum Protein Binding and Pharmacokinetic Behavior of Sulfadimethoxine in Rabbits, Dogs and Rats
- SPECIES DIFFERENCE IN PROTEIN BINDING DISPLACEMENT OF SULFADIMETHOXINE
- EFFECT OF PHENYLBUTAZONE ON SERUM PROTEIN BINDING OF SULFADIMETHOXINE IN DIFFERENT ANIMAL SPECIES
- MODEL ANALYSIS OF INTERFACIAL TRANSFER AND ABSORPTION BEHAVIOR OF DRUG FOLLOWING DISSOLUTION FROM COMPRESSED TABLET : IN THE CASES OF SULFONAMIDES AND β-CYCLODEXTRIN COMPLEXES
- IMPROVEMENT OF ORAL BIOAVAILABILITY OF PREDNISOLONE BY β-CYCLODEXTRIN COMPLEXATION IN HUMANS
- ENHANCED ORAL BIOAVAILABILITY OF ANTIINFRAMMATORY DRUG FLURBIPROFEN IN RABBITS BY TRI-O-METHYL-β-CYCLODEXTRIN COMPLEXATION
- IMPROVEMENTS OF SOME PHARMACEUTICAL CHARACTERISTICS OF VARIOUS STEROIDAL DRUGS BY CYCLODEXTRIN COMPLEXATION
- REDUCTION IN THE LOCAL TISSUE TOXICITY OF CHLORPROMAZINE BY β-CYCLODEXTRIN COMPLEXATION
- Study of Interaction of Pranoprofen with Human Serum Albumin : Binding Properties of Enantiomers and Metabolite
- ENANTIOSELECTIVE ORAL BIOAVAILABILITY OF O-ISOVALERYL PROPRANOLOL AS A POTENTIAL PRODRUG OF PROPRANOLOL
- Evaluation for Antioxidant and Renoprotective Activity of Olmesartan Using Nephrectomy Rats
- Interaction of Fluorescent Probe 7-Anilino-4-methylcoumarin-3-(p)-benzoic Acid with Egg Albumin
- A20 Silencing by Lipid Envelope-Type Nanoparticles Enhances the Efficiency of Lipopolysaccharide-Activated Dendritic Cells
- ENHANCED BIOAVAILABILITY OF DIGOXIN BY γ-CYCLODEXTRIN COMPLEXATION
- REDUCTION IN THE LOCAL TOXICITY OF CHLORPROMACINE AND ITS PHOTOPRODUCTS BY CYCLODEXTRIN COMPLEXATION
- PROTECTIVE MECHANISM OF β-CYCLODEXIRIN FOR THE HEMOLYSIS INDUCED WITH PHENOTHIAZINE NEUROLEPTICS IN VITRO
- CYCLODEXTRIN-INDUCED HEMOLYSIS AND SHAPE CHANGES OF HUMAN ERYTHROCYTES IN VITRO
- PROTECTIVE EFFECTS OF CYCLODEXTRINS ON THE HEMOLYSIS INDUCED WITH TRANQUILIZING PHENOTHIAZINES
- PROTECTIVE EFFECTS OF CYCLODEXTRINS ON DRUG-INDUCED HEMOLYSIS IN VITRO
- Nanomolar Quantification and Identification of Various Nitrosothiols by High Performance Liquid Chromatography Coupled with Flow Reactors of Metals and Griess Reagent
- Enhanced Dissolution of Poorly Water-Soluble Drugs by Water-Soluble Gelatin
- THE ROLE OF SERUM PROTEIN BINDING IN THE INTESTINAL ABSORPTION OF DRUGS
- Opposite Effects of Metoclopramide and Propantheline on Intestinal Absorption of Imipramine in Rats
- INTERACTION OF WARFARIN WITH HUMAN SERUM ALBUMIN
- Effect of N-B Transition on the Microenvironment Surrounding ^Cys in Human Serum Albumin
- Unexpectedly Weak Impacts of Decreased p53 and Retinoblastoma Protein Levels on Mutagenesis by 8-Oxo-7, 8-dihydroguanine (8-Hydroxyguanine)
- Effects of insulator cHS4 on transgene expression from plasmid DNA in a positive feedback system(GENETICS, MOLECULAR BIOLOGY, AND GENE ENGINEERING)
- Correction of Frameshift Mutations with Tailed Duplex DNAs
- Effects of Endogenous Proteins and microRNA Target Sequence in a Positive Feedback System
- Effect of the Anchor in Polyethylene Glycol-Lipids on the Transfection Activity of PEGylated Cationic Liposomes Encapsulating DNA
- Efficient Intradermal Delivery of Superoxide Dismutase Using a Combination of Liposomes and Iontophoresis for Protection against UV-Induced Skin Damage
- Reduced Plasma Glucose by Asparagine Synthetase Knockdown in the Mouse Liver
- Activity coefficients of dimethyl-.BETA.-cyclodextrin in aqueous solutions.
- The structure of the cyclodextrin complex. XI. Crystal structure of hexakis-(2,3,6-tri-o-methyl)-.ALPHA.-cyclodextrin-p-iodoaniline monohydrate.
- Production of small nano-sized particles by complex formation between polycations and linearized plasmid DNA at a low pH(METHODS)
- The structure of the cyclodextrin complex. XIV. Crystal structure of hexakis(2,3,6-tri-O-methyl)-.ALPHA.-cyclodextrin-benzaldehyde (1:1) complex.
- The structure of the cyclodextrin complex. XVIII. Crystal structure of .BETA.-cyclodextrin-benzyl alcohol (1:1) complex pentahydrate.
- The structure of the cyclodextrin complex. XV. Crystal structure of hexakis(2,3,6-tri-O-methyl)-.ALPHA.-cyclodextrin-p-nitrophenol(1:1)complex monohydrate.
- The structure of the cyclodextrin complex. XIX Crystal structures of hexakis(2,3,6-tri-O-methyl)-.ALPHA.-cyclodextrin complexes with (S)- and (R)-mandelic acid. Chiral recognition through the induced-fit conformational change of the macrocyclic ring.
- The structure of the cyclodextrin complex. X. Crystal structure of .ALPHA.-cyclodextrin-benzaldehyde (1:1) complex hexahyderate.
- The structure of the cyclodextrin complex. XVI. Crystal structure of heptakis(2,3,6-tri-O-methyl)-.BETA.-cyclodextrin-p-iodophenol(1:1) complex tetrahydrate.