Production of small nano-sized particles by complex formation between polycations and linearized plasmid DNA at a low pH(METHODS)
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概要
- 論文の詳細を見る
We report on the technical advance of linearized pDNA (pDNA_<linear>) above the circular one (pDNA_<circ>) for preparation of small-sized DNA/polycation complexes (DPC) at a low pH. Also, the resistance of the DPC formed with pDNA_<linear> against poly-L-asparagine indicates that effective ion-pairing occurred between the pDNA_<linear> and polycations.
著者
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Harashima Hideyoshi
Faculty Of Pharmaceutical Science The University Of Tokushima
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Akita Hidetaka
Faculty of Pharmaceutical Sciences, Hokkaido University
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Togashi Ryohei
Faculty of Pharmaceutical Sciences, Hokkaido University
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- Production of small nano-sized particles by complex formation between polycations and linearized plasmid DNA at a low pH(METHODS)