Effects of Fatty Acids on Serum Binding between Furosemide and Valproic Acid
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概要
- 論文の詳細を見る
The effects of fatty acids, including oleate, on the interaction between furosemide and valproic acid in sera at respective serum therapeutic concentration levels were investigated using an ultrafiltration technique. The free fraction of furosemide was significantly increased in the presence of valproic acid. Mutual displacement experiments indicated that furosemide and valproic acid share a common high affinity binding site on human serum albumin (HSA). The serum free fraction of furosemide was increased by the presence of six or more fatty acid molecules per HSA molecule. This fatty acid-induced increase in the unbound fraction of furosemide was further increased by the binding of valproic acid. However, the inhibition of furosemide binding to serum for a fatty acid-valproic acid-furosemide system is nearly the same as the additive effect of fatty acid and valproic acid on the furosemide to serum. Thus, the mechanism for the displacement of HSA-bound furosemide by valproic acid was concluded to be different from that for fatty acid-catalyzed displacement.
- 公益社団法人日本薬学会の論文
- 1998-02-15
著者
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Maruyama Toru
Department of Medicine and Biosystemic Science, Kyushu University
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OTAGIRI Masaki
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University
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Suenaga A
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Suenaga Ayaka
Graduate School Of Pharmaceutical Sciences Kumamoto University
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SHINOZAWA Shinya
Department of Pharmacy, Miyazaki Medical College
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Otagiri M
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Otagiri Masaki
Department Of Biopharmaceutics Graduate School Of Pharmaceutical Sciences
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SUENAGA Ayaka
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Kumamoto University
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TAKAMURA Norito
Department of Pharmacy, Miyazaki Medical College Hospital
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Otagiri M
Kumamoto Univ. Kumamoto Jpn
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Maruyama Toru
Graduate School Of Pharmaceutical Sciences Kumamoto Univ.
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Takamura N
Department Of Pharmacy Miyazaki Medical College Hospital:department Of Pharmaceutics Faculty Of Phar
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Maruyama Toru
Department Of Bioclimatology And Medicine Medical Institute Of Bioregulation Kyushu University
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Shinozawa Shinya
Department Of Pharmacy Miyazaki Medical College Hospital
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Shinozawa Shinya
Department Of Pharmacy Miyazaki Medical College
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