Improvement of Chemical Instability of Carmoful in β-Cyclodextrin Solid Complex by Utilizing Some Organic Acids(Pharmaceutical)
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概要
- 論文の詳細を見る
Degradation of carmoful (HCFU) in the solid state was significantly accelcrated by β-cyclodextrin (β-CyD) complexation owing to the hygroscopic nature of β-CyD. The instability of HCFU in the solid complex was found to be markedly improved by the addition of some organic acids such as citric, L-(+)-tartaric and DL-malic acids, whereats DL-aspartic acid and neutral additives such as talc, lactose, cellulose and methyl cellulose had insignificant stabilizing effects. The results indicated that organic acids having lower pK_a value and higher aqueous solubility are particularly useful to prevent the hydrolysis of HCFU by providing an acidic environment around the complex after moisture sorption.
- 公益社団法人日本薬学会の論文
- 1987-01-25
著者
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上釜 兼人
熊本大学 歯
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平山 文俊
Faculty Of Pharmaceutical Sciences Sojo University
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平山 文俊
Faculty Of Pharmaceutical Sciences Kyushu University
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上釜 兼人
Faculty Of Pharmaceutical Sciences Kumamoto University
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菊池 雅彦
Faculty Of Pharmaceutical Sciences Kumamoto University
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Hirayama Fumitoshi
Faculty Of Pharmaceutical Sciences Sojo University
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上釜 兼人
崇城大 薬
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