Involvement of Calmodulin Inhibition in Analgesia Induced With Low Doses of Intrathecal Trifluoperazine
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概要
- 論文の詳細を見る
We examined which of the known properties of trifluoperazine, including calmodulin inhibition, are involved in its analgesic effect. Furthermore, we tried to find any possible interaction between opioidergic system and calmodulin inhibition-induced analgesia. Intrathecal trifluoperazine (1, 10, 100 μg) showed a biphasic effect in the formalin test; i.e., analgesia at relatively low doses (1, 10 μg) and hyperalgesia at a high dose (100 μg). No analgesic effects were observed after intrathecal injection of sulpiride (1, 10, 100 μg), atropine (0.1, 1, 10 μg), phentolamine (0.1, 1, 10 μg) and brompheniramine (0.1, 1, 10 μg). Meanwhile, intrathecal calmidazolium (10, 50, 250 μg) induced a dose-dependent analgesia. Histamine (1 μg), physostigmine (1 μg), bromocriptine (1 μg) and norepinephrine (1 μg) did not affect trifluoperazine-induced analgesia. Calcium (20 μg) attenuated the antinociceptive effect of trifluoperazine and inhibited the analgesic effect of calmidazolium. Finally, naloxone (2 mg/kg) decreased trifluoperazine-induced antinociception but did not have any effects on calmidazolium-induced analgesia. We concluded that calmodulin inhibition may be involved in the analgesia produced by trifluoperazine. With increasing doses of trifluoperazine, the algesic effect seems to overcome the analgesic effect. It is also suggested that the opioidergic system does not interact with calmodulin inhibition-induced analgesia even though this system has a possible role in trifluoperazine-induced analgesia.
- 社団法人 日本薬理学会の論文
- 2002-02-01
著者
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入江 徹美
熊本大・薬
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入江 徹美
熊本大学 薬 製剤
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Moriuchi Hiroshi
Lab. Of Pharmacy Practice Fac. Of Pharmaceutical Sciences Sojo Univ.
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Moriuchi Hiroshi
熊本大学 医学薬学研究部薬剤情報分析学
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Moriuchi Hiroshi
熊本大学 医学薬学研究部薬剤情報分析学分野
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Irie Tetsumi
Department of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamo
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Irie T
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Irie Tetsumi
Dep. Of Clinical Chemistry And Informatics Graduate School Of Pharmaceutical Sciences Kumamoto Univ.
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Irie Tetsumi
Department Of Clinical Chemistry & Informatics Kumamoto University
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GOLBIDI Saeid
Department of Physiology and Pharmacology, Kashan University of Medical Sciences
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MORIUCHI Hiroshi
Department of Clinical Chemistry and Informatics, Graduate School of Medical and Pharmaceutical Scie
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GHAFGHAZI Taghi
Department of Pharmacology, Isfahan University of Medical Sciences
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HAJHASHEMI Valiollahe
Department of Pharmacology, Isfahan University of Medical Sciences
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Golbidi Saeid
Department Of Physiology And Pharmacology Kashan University Of Medical Sciences
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Ghafghazi Taghi
Department Of Pharmacology Isfahan University Of Medical Sciences
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Hajhashemi Valiollahe
Department Of Pharmacology Isfahan University Of Medical Sciences
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Golbidi Saeid
Department of Pharmacology, Isfahan University of Medical Sciences
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