A Selective Thromboxane A2 (TXA2) Synthase Inhibitor, Ozagrel, Attenuates Lung Injury and Decreases Monocyte Chemoattractant Protein-1 and Interleukin-8 mRNA Expression in Oleic Acid–Induced Lung Injury in Guinea Pigs
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概要
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This study examined the effect of ozagrel, a thromboxane A2 synthase inhibitor, on the accumulation of leucocytes and chemokine mRNA expression in lungs experimentally injured using oleic acid (OA). OA injection into guinea pigs rapidly increased thromboxane A2 generation and subsequently increased total protein concentration and the numbers of macrophages and neutrophils in bronchoalveolar lavage fluid and increased monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in the whole lung. Administration of ozagrel prevented these changes associated with OA injection. Ozagrel is a promising drug candidate for preventing acute lung injury.
- 社団法人 日本薬理学会の論文
著者
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Moriuchi Hiroshi
Lab. Of Pharmacy Practice Fac. Of Pharmaceutical Sciences Sojo Univ.
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Moriuchi Hiroshi
熊本大学 医学薬学研究部薬剤情報分析学
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Moriuchi Hiroshi
Laboratory Of Nutrition Biochemistry National Food Research Institute Ministry Of Argiculture Forest
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Moriuchi Hiroshi
熊本大学 医学薬学研究部薬剤情報分析学分野
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Ishitsuka Yoichi
Department of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamo
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Irikura Mitsuru
Department of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamo
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Irie Tetsumi
Department Of Clinical Chemistry & Informatics Kumamoto University
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Iyama Ken-ichi
Department Of Pathology Institute Of Constitutional Medicine Kumamoto University
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TOKUNAGA HIDEHIRO
Department of Surgical Pathology, Kumamoto University School of Medicine
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Ishitsuka Yoichi
Dep. Of Clinical Chemistry And Informatics Graduate School Of Pharmaceutical Sciences Kumamoto Univ.
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Kurita Sumika
Department Of Clinical Chemistry And Informatics Faculty Of Medical And Pharmaceutical Sciences Kuma
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Hatamoto Keita
Department Of Clinical Chemistry And Informatics Faculty Of Medical And Pharmaceutical Sciences Kuma
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Isohama Yoichiro
Department Of Chemico-pharmacological Sciences Graduate School Of Pharmaceutical Sciences Kumamoto U
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Tokunaga Hidehiro
Department Of Surgical Pathology Kumamoto University Hospital
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Irikura Mitsuru
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
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Ishitsuka Yoichi
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
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Irikura Mitsuru
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
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Kurita Sumika
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
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Irie Tetsumi
Department of Clinical Chemistry and Informatics, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Japan
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Moriuchi Hiroshi
Laboratory of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Sojo University, Japan
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