Effects of Bolus Injection of Soybean-Based Fat Emulsion and Fatty Acids on Pulmonary Gas Exchange Function(Pharmacology)

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To determine whether or not a "bolus injection" of soybean-based fat emulsion (SFE), which contains oleic acid (OA), a potent lung-toxic unsaturated C-18 fatty acid, can induce pulmonary dysfunction, we examined the effect of SFE injection on the partial oxygen pressure of arterial blood (Pao_2) and pulmonary vascular permeability. In addition, we compared the effect of an injection of SFE with that of OA, soybean oil (a source of SFE), emulsified OA and C-18 fatty acids. Bolus injection of SFE (0.3-4.8ml/kg) had little effect on Pao_2 and pulmonary vascular permeability. Injection of an equivalent amount of OA, on the other hand, significantly decreased Pao_2 and increased pulmonary vascular hyper-permeability. This decrease in Pao_2 was attenuated by emulsification. Unemulsified soybean oil also induced a decrease in Pao_2, although the effect was weaker than that of OA. Other unsaturated C-18 fatty acids (linoleic and linolenic acid) induced a decrease in Pao_2 as potent as OA while stearic acid, a C-18 saturated fatty acid, had little effect. Although we did not observe pulmonary toxicity as a result of "bolus injection" of SFE, the chemical form, for example, emulsification and the degree of saturability of the carbon chain, seems to influence the pulmonary toxicities of lipids and fatty acids. Furthermore, the potent pulmonary toxicity of OA seems to depend not only on pulmonary vascular embolization but also pharmacological and/or inflammation-inducing properties.
公益社団法人日本薬学会の論文
2009-03-01

Effects of Bolus Injection of Soybean-Based Fat Emulsion and Fatty Acids on Pulmonary Gas Exchange Function(Pharmacology)

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